努力构建完美的体外口腔药物吸收模型。
Striving Towards the Perfect In Vitro Oral Drug Absorption Model.
机构信息
Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
Trends Pharmacol Sci. 2019 Oct;40(10):720-724. doi: 10.1016/j.tips.2019.07.010. Epub 2019 Aug 16.
PMID:31422894
Abstract
Oral drug delivery systems have multiple goals, assessing and enabling intestinal absorption at efficacious doses being one of them. Here we highlight the in vitro advances in modeling drug absorption, which more faithfully reflect human intestinal physiology and reduce the reliance on animal models.
摘要
口服药物递送系统有多个目标，其中之一是评估和实现有效的肠道吸收。在这里，我们重点介绍了在模拟药物吸收方面的体外进展，这些进展更能真实反映人体肠道生理学，并减少对动物模型的依赖。
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