Ye Zhongrui, Zhang Bo, Chen Yu, Lin Jiang
Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang 317000, P.R. China.
Oncol Lett. 2019 Aug;18(2):1311-1317. doi: 10.3892/ol.2019.10394. Epub 2019 May 22.
Clinical efficacy of single utility port video-assisted thoracoscopic surgery (VATS) and three-port VATS for patients with non-small cell lung cancer (NSCLC) was compared. A total of 156 patients with NSCLC who underwent VATS in Taizhou Hospital of Zhejiang Province from July 2015 to January 2017 were selected as subjects. They were randomly divided into group A (n=74) and group B (n=82), in which group A was treated with single utility port VATS and group B was treated with three-port VATS. Perioperative indicators such as operation time, intraoperative blood loss, postoperative drainage, removal of drainage tube, lymph node dissection, hospitalization time, postoperative complications, postoperative pain and postoperative quality of life were observed. Expression levels of CRP and IL-6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). There was no significant difference in the operation time, postoperative drainage volume, drainage tube removal time and lymph node dissection between groups A and B (P>0.05). Blood loss and hospitalization time in group A were significantly lower than those in group B (P<0.001). VAS scores at 1-3 days after operation in group A were significantly lower than those in group B (P<0.001). Levels of serum CRP and IL-6 at 1-7 days after operation in group A were significantly lower than those in group B (P<0.001). Incidence of complication in group A was not significantly different from that in group B (P>0.05). Overall quality of life scores of group A and B were significantly lower than the preoperative scores (P<0.001). Overall status score of group A was significantly higher than that of group B (P<0.001). Clinical efficacies of single utility port VATS and three-port VATS were similar. Single utility port VATS can reduce trauma during surgery, reduce stress response, relieve postoperative pain, and facilitate the recovery of postoperative quality of life.
比较单操作孔电视辅助胸腔镜手术（VATS）与三操作孔VATS治疗非小细胞肺癌（NSCLC）患者的临床疗效。选取2015年7月至2017年1月在浙江省台州医院接受VATS治疗的156例NSCLC患者作为研究对象。将其随机分为A组（n = 74）和B组（n = 82），其中A组采用单操作孔VATS治疗，B组采用三操作孔VATS治疗。观察手术时间、术中出血量、术后引流量、引流管拔除情况、淋巴结清扫情况、住院时间、术后并发症、术后疼痛及术后生活质量等围手术期指标。采用酶联免疫吸附测定（ELISA）法检测血清中CRP和IL-6的表达水平。A组与B组在手术时间、术后引流量、引流管拔除时间及淋巴结清扫方面差异无统计学意义（P>0.05）。A组术中出血量及住院时间明显低于B组（P<0.001）。A组术后1 - 3天的视觉模拟评分（VAS）明显低于B组（P<0.001）。A组术后1 - 7天血清CRP和IL-6水平明显低于B组（P<0.001）。A组并发症发生率与B组差异无统计学意义（P>0.05）。A组和B组的总体生活质量评分均明显低于术前评分（P<0.001）。A组的总体状况评分明显高于B组（P<0.001）。单操作孔VATS与三操作孔VATS的临床疗效相似。单操作孔VATS可减少手术创伤，减轻应激反应，缓解术后疼痛，促进术后生活质量的恢复。
