Gidday Jeffrey M
Departments of Ophthalmology, Physiology, and the Neuroscience Center of Excellence, Louisiana State University School of Medicine, New Orleans, LA 70112.
Cond Med. 2018 Feb;1(2):85-97. Epub 2018 Feb 15.
Although both preclinical and clinical conditioning studies in heart and brain lead the field of conditioning medicine, investigations of retinal conditioning still number more than 100. In this brief review, we highlight findings to date from animal and cell culture models of conditioning that provide demonstrated protection in acute and chronic retinal injury and disease models. The multitude of stimuli used to condition the retina, the signaling mediators and pathways identified, and the injury- and disease-resilient phenotypes documented are discussed herein, along with our recommendations for the kinds of studies needed to continue to advance this promising field. In our view, the robust protection afforded by these adaptive epigenetic responses to conditioning stress provides significant incentives for both furthering our investment in bench research and underwriting clinical trials, so that the full potential of this therapy can be realized.
尽管心脏和大脑的临床前和临床条件反射研究引领着条件反射医学领域，但视网膜条件反射的研究数量仍超过100项。在这篇简短的综述中，我们重点介绍了迄今为止在条件反射动物和细胞培养模型中的研究结果，这些研究在急性和慢性视网膜损伤及疾病模型中提供了已证实的保护作用。本文讨论了用于视网膜条件反射的多种刺激、已确定的信号介质和途径，以及记录的抗损伤和抗病表型，同时还提出了我们对继续推动这一有前景领域所需研究类型的建议。我们认为，这些对条件反射应激的适应性表观遗传反应所提供的强大保护，为进一步加大对基础研究的投入和资助临床试验提供了重要动力，以便能够实现这种疗法的全部潜力。
