Tudor R G, Youngs D J, Yoshioka K, Burdon D W, Keighley M R
Department of Surgery, General Hospital, Birmingham, United Kingdom.
Arch Surg. 1988 Dec;123(12):1487-90. doi: 10.1001/archsurg.1988.01400360057008.
A low-mortality model of an intra-abdominal abscess in the rat has been used to study the penetration of two quinolone agents into pus. Maximum concentrations in pus after intravenous injections were achieved at four hours (ciprofloxacin: 12.7 +/- 3.69 mg/L, fleroxacin: 2.25 +/- 1.82 mg/L), whereas fleroxacin given orally reached the maximum level at two hours (13.39 +/- 3.13 mg/L). Higher concentrations of fleroxacin were recorded in pus than in serum at each time point up to eight hours after administration, but pus levels of ciprofloxacin only exceeded serum levels after 1.5 hours. These antibiotics appear to have a unique property of high penetration into established abscesses and may have an important therapeutic role in the treatment of patients with multiple interloop abscesses.
一种大鼠腹腔内脓肿的低死亡率模型已被用于研究两种喹诺酮类药物在脓液中的渗透情况。静脉注射后，在4小时时脓液中达到最大浓度（环丙沙星：12.7±3.69毫克/升，氟罗沙星：2.25±1.82毫克/升），而口服氟罗沙星在2小时时达到最高水平（13.39±3.13毫克/升）。给药后长达8小时的每个时间点，脓液中记录到的氟罗沙星浓度均高于血清中的浓度，但环丙沙星的脓液水平仅在1.5小时后超过血清水平。这些抗生素似乎具有高渗透已形成脓肿的独特特性，可能在治疗多发性肠袢间脓肿患者中发挥重要的治疗作用。
