Cassidy S B, Niblack G D, Lorber C A, Mann J M, Engel E
Ann Genet. 1978 Dec;21(4):203-8.
In a preliminary study of twenty-three patients with gonadal dysgenesis (Turner's syndrome) and their families, correlation was sought between their serum defined HLA allele frequencies and their known tendencies toward abnormal immune responses and diabetes mellitus, since individuals with the latter disorders have been shown to have an increased frequency of certain HLA types. We were unable to demonstrate an association between these major serum-defined histocompatibility antigens, immune homeostasis disturbances and sex chromosome aneuploidy in this group. It is felt, however, that testing involving the patterns of HLA-D and "HLA-D related" antigen frequencies should be obtained to further evaluate the possibility of such an association.
在一项对23例性腺发育不全（特纳综合征）患者及其家族的初步研究中，鉴于已表明患有免疫反应异常和糖尿病的个体中某些HLA类型的频率增加，因此研究了他们血清中确定的HLA等位基因频率与已知的异常免疫反应倾向和糖尿病倾向之间的相关性。在该组中，我们未能证明这些主要血清定义的组织相容性抗原、免疫稳态紊乱和性染色体非整倍体之间存在关联。然而，有人认为，应该进行涉及HLA-D和“与HLA-D相关”抗原频率模式的检测，以进一步评估这种关联的可能性。
