Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea.
Department of Pharmaceutical Biochemistry, Kyung Hee University, Seoul 02447, Korea.
Nutrients. 2019 Aug 16;11(8):1928. doi: 10.3390/nu11081928.
Metabolites related to dietary factors can be used to identify biological markers to prevent metabolic disease. However, most studies have been conducted in the United States and Europe, and those in the Asian region are limited. We investigated the effects of dietary monounsaturated fatty acids (MUFAs) and metabolites on new-onset hypertension in the Korean Genome and Epidemiology Study.
A total of 1529 subjects without hypertension were divided into tertiles of dietary MUFAs intake. After a 4-year follow-up, 135 serum metabolites were measured using the AbsoluteIDQ p180 kit. During the 4-year follow-up period, 193 new-onset hypertension incidences were observed. The highest MUFAs intake group was inversely associated with the risk of hypertension compared with the lowest MUFAs intake group (odds ratio (OR) = 0.49, (95% confidence interval (CI) = 0.29-0.82)). Of the 135 metabolites, eight were significantly associated with MUFAs intake. Phosphatidylcholine-diacyl (PC aa) C 38:1 and hydroxysphingomyelin (SM OH) C 16:1 were associated with a decrease in hypertension risk (PC aa C 38:1, OR = 0.60 (95% CI = 0.37-0.96); SM OH C 16:1, OR = 0.42 (95% CI = 0.20-0.90)). The highest MUFAs intake group had a significantly decreased risk of hypertension, even considering PC aa C 38:1 and SM (OH) C 16:1 as a mediator.
We confirmed that dietary MUFAs intake, and PC aa C 38:1 and SM (OH) C 16:1 had protective effects against hypertension. Furthermore, high MUFAs intake combined with PC aa C 38:1 and SM (OH) C 16:1 has the most significant effect on reducing the risk hypertension.
与饮食因素相关的代谢产物可用于鉴定预防代谢疾病的生物标志物。然而，大多数研究都在美国和欧洲进行，亚洲地区的研究有限。我们在韩国基因组与流行病学研究中调查了饮食中单不饱和脂肪酸（MUFAs）和代谢产物对新发高血压的影响。
共纳入 1529 例无高血压的受试者，按饮食 MUFAs 摄入量分为三分位组。随访 4 年后，使用 AbsoluteIDQ p180 试剂盒测量了 135 种血清代谢产物。在 4 年随访期间，观察到 193 例新发高血压病例。与最低 MUFAs 摄入量组相比，MUFAs 摄入量最高组患高血压的风险呈反比（比值比（OR）=0.49，95%置信区间（CI）=0.29-0.82））。在 135 种代谢产物中，有 8 种与 MUFAs 摄入量显著相关。二酰基磷脂酰胆碱（PC aa）C38:1 和羟基神经酰胺（SM OH）C16:1 与降低高血压风险相关（PC aa C38:1，OR=0.60（95%CI=0.37-0.96）；SM OH C16:1，OR=0.42（95%CI=0.20-0.90））。即使考虑到 PC aa C38:1 和 SM（OH）C16:1 作为中介，MUFAs 摄入量最高组患高血压的风险也显著降低。
我们证实，饮食 MUFAs 摄入量以及 PC aa C38:1 和 SM（OH）C16:1 对高血压具有保护作用。此外，高 MUFAs 摄入量与 PC aa C38:1 和 SM（OH）C16:1 联合使用对降低高血压风险的效果最为显著。
