Kim Kyuwoong, Chang Yoonjung
Division of Cancer Control and Policy, National Cancer Control Institute, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea.
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.
BMC Public Health. 2022 Mar 17;22(1):518. doi: 10.1186/s12889-022-12962-y.
Little is known about the association of secondhand smoke (SHS) exposure with cardiometabolic health in adult cancer survivors, especially those who have never smoked. This study aimed to investigate the association of SHS exposure and cardiometabolic health in never-smoking adult cancer survivors.
Cross-sectional data of 830 adult cancer survivors aged more than 19 years who were never-smokers were identified from the Korea National Health and Nutrition Survey (KNHANES) 2013-2018, a nationally representative sample of the noninstitutionalized Korean population. SHS exposure was defined from self-reported survey and cardiometabolic outcomes (hypertension, general and abdominal obesity, hyperlipidemia, hypertriglyceridemia, reduced high-density lipoprotein, and impaired fasting glucose) were determined according to relevant criteria and data from the KNHANES. We used multiple logistic regression to compute odds ratio (OR) and 95% confidence intervals (95% CI) comparing those with and without SHS exposure for each outcome adjusted for potential confounders.
Compared with the never-smoking adult cancer survivors without SHS exposure, those with SHS exposure had significantly higher odds for hypertriglyceridemia (OR = 1.63; 95% CI: 1.07-2.48). However, the other outcomes showed nonsignificant associations with SHS exposure (hypertension [OR = 1.33; 95% CI: 0.90-1.96]. general obesity [OR = 1.47; 95% CI: 1.47: 0.97-2.22], abdominal obesity [OR = 1.20; 95% CI: 0.82-1.75], hyperlipidemia [OR = 1.03; 95% CI: 0.68-1.55], reduced HDL-cholesterol [OR = 1.01; 95% CI: 0.70-1.45], and impaired fasting glucose [OR = 1.07; 95% CI: 0.72-1.58].
This cross-sectional study suggests the association of SHS exposure with hypertriglyceridemia and provides evidence for marginal associations with other cardiometabolic risk factors in never-smoking adult cancer survivors. More studies are needed to develop evidence-based public health policies to minimize SHS exposure in adult cancer survivors.
关于二手烟暴露与成年癌症幸存者心脏代谢健康之间的关联，人们了解甚少，尤其是那些从不吸烟的幸存者。本研究旨在调查从不吸烟的成年癌症幸存者中二手烟暴露与心脏代谢健康之间的关联。
从2013 - 2018年韩国国家健康与营养调查（KNHANES）中识别出830名年龄超过19岁且从不吸烟的成年癌症幸存者的横断面数据，该调查是韩国非机构化人口的全国代表性样本。二手烟暴露通过自我报告的调查来定义，心脏代谢结果（高血压、全身性肥胖和腹部肥胖、高脂血症、高甘油三酯血症、高密度脂蛋白降低以及空腹血糖受损）根据相关标准和KNHANES的数据来确定。我们使用多元逻辑回归来计算比值比（OR）和95%置信区间（95%CI），比较有和没有二手烟暴露的人群在调整潜在混杂因素后的每种结果。
与没有二手烟暴露的从不吸烟成年癌症幸存者相比，有二手烟暴露的幸存者患高甘油三酯血症的几率显著更高（OR = 1.63；95%CI：1.07 - 2.48）。然而，其他结果显示与二手烟暴露的关联不显著（高血压[OR = 1.33；95%CI：0.90 - 1.96]、全身性肥胖[OR = 1.47；95%CI：0.97 - 2.22]、腹部肥胖[OR = 1.20；95%CI：0.82 - 1.75]、高脂血症[OR = 1.03；95%CI：0.68 - 1.55]、高密度脂蛋白胆固醇降低[OR = 1.01；95%CI：0.70 - 1.45]以及空腹血糖受损[OR = 1.07；95%CI：0.72 - 1.58]）。
这项横断面研究表明二手烟暴露与高甘油三酯血症之间存在关联，并为从不吸烟的成年癌症幸存者中与其他心脏代谢风险因素的边缘关联提供了证据。需要更多研究来制定基于证据的公共卫生政策，以尽量减少成年癌症幸存者中的二手烟暴露。
