Kosnai I, Kuitunen P, Siimes M A
Arch Dis Child. 1979 May;54(5):375-8. doi: 10.1136/adc.54.5.375.
24 children in whom coeliac disease had been diagnosed between one and 10 years earlier were re-examined for intestinal loss of iron and activity of the disease. Mild iron deficiency by laboratory criteria and by response to iron medication was common. The children with biopsy evidence of flat mucosa or intraepithelial lymphocytosis had a greater iron loss in their stools than those patients with normal, or almost normal, histology. The data suggest that loss of iron was mainly due to intestinal blood loss rather than to shedding of mucosal cells. We conclude that treatment with iron is indicated in many children with coeliac disease as the increased losses of iron persist for long periods although absorption of iron seems to improve or be negligibly affected.
对24名在1至10年前被诊断患有乳糜泻的儿童进行了复查，以检查铁的肠道流失情况和疾病活动度。根据实验室标准以及对铁剂治疗的反应，轻度缺铁情况很常见。经活检证明有黏膜扁平或上皮内淋巴细胞增多的儿童，其粪便中的铁流失量比组织学正常或几乎正常的患者更多。数据表明，铁流失主要是由于肠道失血，而非黏膜细胞脱落。我们得出结论，许多乳糜泻儿童都需要进行铁剂治疗，因为尽管铁的吸收似乎有所改善或受到的影响可忽略不计，但铁流失的增加会持续很长时间。
