血清 25-羟维生素 D 浓度与苏丹北部成年人高血压的相关性：一项基于社区的横断面研究。

Association between serum 25-hydroxyvitamin D concentrations and hypertension among adults in North Sudan: a community-based cross-sectional study.

机构信息

Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Department of Pathology, AlQunfudhah Faculty of Medicine, Umm Al-Qura University, Al Qunfudhah, Saudi Arabia.

出版信息

BMC Cardiovasc Disord. 2023 Aug 17;23(1):402. doi: 10.1186/s12872-023-03432-3.

DOI:10.1186/s12872-023-03432-3

PMID:37592222

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10433536/

Abstract

BACKGROUND

Globally, hypertension represents a major public health problem. The association between 25-hydroxyvitamin D (25[OH]D) levels and hypertension remains unclear. The current study aimed to investigate the association between serum 25(OH)D levels and hypertension among adults in Sudan.

METHODS

A community-based cross-sectional study was conducted among adults in North Sudan. Sociodemographic and clinical data were collected using a questionnaire and face-to-face interviews. Serum 25(OH)D was measured using an enzyme-linked immunosorbent assay. Multivariate logistic regression and multiple linear regression analyses were performed.

RESULTS

Of the total of 391 participants, 202 (51.7%) were females. The median (interquartile range [IQR]) of participants' ages was 45(32-55) years. Of the total, 219(56.0%) had hypertension. The median (IQR) of serum25(OH)D was 13.3(9.9-19.7) ng/mL, and 295 (75.4%) participants had vitamin D deficiency (< 20 ng/mL). In multivariable logistic regression, the adjusted odds ratio (AOR) for age = 1.05, 95% confidence interval (CI)1.03‒1.061, the AOR for being female = 2.02, 95% CI, 1.12‒3.66, and body mass index was AOR = 1.09, 95% CI, 1.05‒1.14, all of which were significantly associated with hypertension. However, serum 25(OH)D levels were not associated with hypertension (AOR = 1.01, 95% CI 0.99‒1.05, P = 0.317). In multiple linear regression, while systolic blood pressure was negatively associated with 25(OH)D (coefficient = - 0.28, P = 0.017), there was no significant association between serum 25(OH)D level and diastolic blood pressure (coefficient = - 0.10, P = 0.272) or mean blood pressure (coefficient =-0.03, P = 0.686).

CONCLUSION

The current study revealed a negative association between vitamin D and systolic blood pressure. The mechanism of such an association needs further study.

摘要

背景

全球范围内，高血压是一个主要的公共卫生问题。25-羟维生素 D（25[OH]D）水平与高血压之间的关系仍不清楚。本研究旨在探讨苏丹成年人血清 25（OH）D 水平与高血压之间的关系。

方法

这是一项在北苏丹进行的基于社区的横断面研究。使用问卷和面对面访谈收集社会人口统计学和临床数据。使用酶联免疫吸附试验测量血清 25（OH）D。进行多变量逻辑回归和多元线性回归分析。

结果

在总共 391 名参与者中，有 202 名（51.7%）为女性。参与者的年龄中位数（四分位距 [IQR]）为 45（32-55）岁。总共 219 名（56.0%）患有高血压。血清 25（OH）D 的中位数（IQR）为 13.3（9.9-19.7）ng/mL，295 名（75.4%）参与者维生素 D 缺乏（<20ng/mL）。在多变量逻辑回归中，年龄的调整后优势比（AOR）为 1.05，95%置信区间（CI）为 1.03-1.061，女性的 AOR 为 2.02，95%CI 为 1.12-3.66，体重指数的 AOR 为 1.09，95%CI 为 1.05-1.14，均与高血压显著相关。然而，血清 25（OH）D 水平与高血压无关（AOR=1.01，95%CI 0.99-1.05，P=0.317）。在多元线性回归中，收缩压与 25（OH）D 呈负相关（系数=-0.28，P=0.017），而血清 25（OH）D 水平与舒张压（系数=-0.10，P=0.272）或平均血压（系数=-0.03，P=0.686）之间无显著关联。