VIB Center for Inflammation Research, 9052 Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.
Cold Spring Harb Perspect Biol. 2020 Jan 2;12(1):a036418. doi: 10.1101/cshperspect.a036418.
A20 is a potent anti-inflammatory protein, acting by inhibiting nuclear factor κB (NF-κB) signaling and inflammatory gene expression and/or by preventing cell death. Mutations in the gene have been associated with a plethora of inflammatory and autoimmune pathologies in humans and in mice. Although the anti-inflammatory role of A20 is well accepted, fundamental mechanistic questions regarding its mode of action remain unclear. Here, we review new findings that further clarify the molecular and cellular mechanisms by which A20 controls inflammatory signaling and cell death, and discuss new evidence for its involvement in inflammatory and autoimmune disease development.
A20 是一种有效的抗炎蛋白，通过抑制核因子 κB（NF-κB）信号和炎症基因表达，或通过防止细胞死亡来发挥作用。基因中的突变与人类和小鼠中大量的炎症和自身免疫性疾病有关。尽管 A20 的抗炎作用已被广泛接受，但关于其作用机制的基本机制问题仍不清楚。在这里，我们回顾了新的发现，这些发现进一步阐明了 A20 控制炎症信号和细胞死亡的分子和细胞机制，并讨论了其在炎症和自身免疫性疾病发展中的新证据。
