埃塞俄比亚东北部德西镇药学专业人员关于孕期用药风险的知识与实践评估：一项横断面研究
Evaluation of Knowledge and Practice of Pharmacy Professionals regarding the Risk of Medication Use during Pregnancy in Dessie Town, Northeast Ethiopia: A Cross-Sectional Study.
作者信息
Tuha Abdu, Gurbie Yilak, Hailu Haftom Gebregergs
机构信息
Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
School of Pharmacy, College Health Sciences, Mekelle University, Mekelle, Ethiopia.
出版信息
J Pregnancy. 2019 Jul 25;2019:2186841. doi: 10.1155/2019/2186841. eCollection 2019.
BACKGROUND
The developing organism is unique in its responsiveness to drugs and predictability of therapeutic effectiveness based on the adult which can lead to grave consequences in the neonate and child. Moreover, uncertainty about the risks of drug use in pregnancy could result in restrictive attitudes towards prescribing and dispensing medicines and their use. Pharmacists have huge duties to improve medication use, especially among pregnant women. The objective of this study is, hence, to assess the knowledge and practice of pharmacy professionals (PPs) towards the risk of medication use during pregnancy.
METHODOLOGY
A questionnaire-based cross-sectional study was carried out over practicing community and hospital pharmacy professionals in Dessie town. They were asked about the safety of common drugs during pregnancy. It involves both prescription-only medications (POM) and over-the-counter (OTC) medications. Secondly, they were asked about their practice towards the risk of medication use during pregnancy. Both descriptive and analytical statistics were utilized. For descriptive analysis, results were expressed as numbers, percentages, and mean (± SD and 95% CI).
RESULT
Seventy-six pharmacy professionals in Dessie, Northeast Ethiopia, took part in the study. Most of the respondents (64.5%) believed that amoxicillin is safe in all trimesters. 26 (34.2%) of participants knew that isotretinoin is unsafe for use by pregnant women. About dietary supplements, 32.9% of PPs reported that Vitamin A supplements are safe in all trimesters. There was a significant difference observed for study college and years of experience of the PPs in their score of knowledge test (p=0.020 and p=0.024, respectively). Additionally, there was a difference seen for gender (p=0.030), study college (p=0.036), and working institution (p=0.013) in their advice to pregnant women.
CONCLUSION AND RECOMMENDATION
Overall, PPs exhibited very low knowledge about drug safety during pregnancy. The absence of obligatory continuing pharmacy education for pharmacists is expected to have negatively affected the level of medication knowledge and consequently the pharmaceutical care services delivered in community and hospital pharmacies. As medication knowledge of PPs is poor, a multitude of strategies (educational, economic, managerial, and regulatory) should be designed by the government, universities, and pharmaceutical associations to improve the pharmacy professionals' role in the healthcare system by providing them with continuous and up-to-date medication knowledge.
背景
发育中的生物体对药物的反应以及基于成人情况的治疗效果可预测性具有独特性，这可能给新生儿和儿童带来严重后果。此外，孕期用药风险的不确定性可能导致对开药、配药及其使用采取限制态度。药剂师在改善用药情况方面，尤其是孕妇用药方面，肩负着重大责任。因此，本研究的目的是评估药学专业人员（PPs）对孕期用药风险的知识和实践情况。
方法
对德西镇的社区和医院执业药学专业人员开展了一项基于问卷的横断面研究。询问他们关于孕期常用药物的安全性，这涉及仅凭处方使用的药物（POM）和非处方药（OTC）。其次，询问他们对孕期用药风险的实践情况。采用了描述性和分析性统计方法。对于描述性分析，结果以数字、百分比和均值（±标准差和95%置信区间）表示。
结果
埃塞俄比亚东北部德西镇的76名药学专业人员参与了该研究。大多数受访者（64.5%）认为阿莫西林在孕期各阶段都是安全的。26名（34.2%）参与者知道异维A酸对孕妇不安全。关于膳食补充剂，32.9%的药学专业人员报告称维生素A补充剂在孕期各阶段都是安全的。在知识测试得分方面，PPs的学习院校和工作年限存在显著差异（分别为p = 0.020和p = 0.024）。此外，在给孕妇的建议方面，性别（p = 0.030）、学习院校（p = 0.036）和工作机构（p = 0.013）存在差异。
结论与建议
总体而言，PPs对孕期药物安全性的知识掌握程度很低。药剂师缺乏强制性的继续药学教育预计对用药知识水平产生了负面影响，进而影响了社区和医院药房提供的药学服务。由于PPs的用药知识较差，政府、大学和制药协会应制定多种策略（教育、经济、管理和监管方面），通过为他们提供持续和最新的用药知识，来改善药学专业人员在医疗保健系统中的作用。
Zotero 插件