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Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial.经皮冠状动脉介入治疗的急性冠状动脉综合征患者的抗血小板治疗降级指导（TROPICAL-ACS）：一项随机、开放标签、多中心试验。
Lancet. 2017 Oct 14;390(10104):1747-1757. doi: 10.1016/S0140-6736(17)32155-4. Epub 2017 Aug 28.
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Should de-escalation of bone-targeting agents be standard of care for patients with bone metastases from breast cancer? A systematic review and meta-analysis.骨转移乳腺癌患者是否应采用降阶治疗骨靶向药物？系统评价和荟萃分析。
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Diabetes and outcomes following guided de-escalation of antiplatelet treatment in acute coronary syndrome patients undergoing percutaneous coronary intervention: a pre-specified analysis from the randomised TROPICAL-ACS trial.糖尿病患者行经皮冠状动脉介入治疗的急性冠状动脉综合征患者抗血小板治疗降级指导后的结局：来自随机 TROPICAL-ACS 试验的预先指定分析。
EuroIntervention. 2019 Aug 9;15(6):e513-e521. doi: 10.4244/EIJ-D-18-01077.

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A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling.从表型组学角度探讨影响乳腺癌治疗的因素：在血液和组织生物标志物分析中整合衰老和生活方式因素。
Front Immunol. 2021 Feb 1;11:616188. doi: 10.3389/fimmu.2020.616188. eCollection 2020.

本文引用的文献

1
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.基于 21 基因表达检测的乳腺癌辅助化疗。
N Engl J Med. 2018 Jul 12;379(2):111-121. doi: 10.1056/NEJMoa1804710. Epub 2018 Jun 3.
2
Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update.止吐药：美国临床肿瘤学会临床实践指南更新。
J Clin Oncol. 2017 Oct 1;35(28):3240-3261. doi: 10.1200/JCO.2017.74.4789. Epub 2017 Jul 31.
3
Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment.一项评估常规癌症治疗期间症状监测的患者报告结局的试验的总生存结果。
JAMA. 2017 Jul 11;318(2):197-198. doi: 10.1001/jama.2017.7156.
4
70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.70 基因特征作为早期乳腺癌治疗决策的辅助手段。
N Engl J Med. 2016 Aug 25;375(8):717-29. doi: 10.1056/NEJMoa1602253.
5
Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.21基因表达检测法在乳腺癌中的前瞻性验证
N Engl J Med. 2015 Nov 19;373(21):2005-14. doi: 10.1056/NEJMoa1510764. Epub 2015 Sep 27.
6
Effectiveness of an Adjuvant Chemotherapy Regimen for Early-Stage Breast Cancer: A Systematic Review and Network Meta-analysis.早期乳腺癌辅助化疗方案的疗效：系统评价和网络荟萃分析。
JAMA Oncol. 2015 Dec;1(9):1311-8. doi: 10.1001/jamaoncol.2015.3062.
7
Progress in adjuvant chemotherapy for breast cancer: an overview.乳腺癌辅助化疗的进展：综述
BMC Med. 2015 Aug 17;13:195. doi: 10.1186/s12916-015-0439-8.
8
Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.美国临床肿瘤学会临床实践指南更新：白细胞生长因子的应用建议。
J Clin Oncol. 2015 Oct 1;33(28):3199-212. doi: 10.1200/JCO.2015.62.3488. Epub 2015 Jul 13.
9
Shared decision making for treatment of cancer: challenges and opportunities.癌症治疗中的共同决策：挑战与机遇。
J Oncol Pract. 2014 May;10(3):206-8. doi: 10.1200/JOP.2014.001434.
10
Does chemotherapy really affect the quality of life of women with breast cancer?化疗真的会影响乳腺癌女性的生活质量吗？
J Breast Cancer. 2013 Jun;16(2):229-35. doi: 10.4048/jbc.2013.16.2.229. Epub 2013 Jun 28.

De-escalation yes, but not at the expense of efficacy: in defense of better treatment.

作者信息

Shapiro Charles L

机构信息

Department of Medicine, Director of Translational Breast Cancer Research, Director of Cancer Survivorship, Icahn School of Medicine, Mount Sinai, NY 10029 USA.

出版信息

NPJ Breast Cancer. 2019 Aug 12;5:25. doi: 10.1038/s41523-019-0120-z. eCollection 2019.

DOI:10.1038/s41523-019-0120-z
PMID:31428678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6690937/
Abstract
摘要