Department of Cardiology and Angiology, University Hospital Giessen, 35390, Giessen, Germany.
Adiphea, Werbach, Germany.
Eur J Appl Physiol. 2019 Oct;119(10):2265-2274. doi: 10.1007/s00421-019-04210-w. Epub 2019 Aug 19.
Low vitamin D levels have been associated with elevated blood pressure in the general population. Prospective studies, however, have produced conflicting evidence about the blood pressure-lowering effects of vitamin D supplementation. Cardiorespiratory fitness may modulate the vitamin D-blood pressure association. We therefore examined this association in professional athletes, whose high training load serves as a biological control for physical fitness.
50 male professional handball players (age 26 ± 5 years) were examined. We assessed the central aortic pressure parameters using transfer function-based analysis of oscillometrically obtained peripheral arterial waveforms. Serum 25-OH vitamin D concentrations were determined by chemiluminescent immunoassay. The threshold for insufficiency was set at values of < 30 ng/mL.
Central blood pressure (cBP) was 98 ± 7/60 ± 10 mmHg. The aortic pulse wave velocity (PWV) was 6.3 ± 1.0 m/s. Nine athletes (18%) displayed insufficient 25-OH vitamin D levels and had a significantly (p < 0.01) higher cBP compared with the 41 (82%) athletes with sufficient 25-OH vitamin D levels (106 ± 5/68 ± 8 vs. 97 ± 7/58 ± 9 mmHg). Central systolic blood pressure (cSBP) in vitamin D-sufficient athletes was significantly lower in comparison to the healthy reference population (97 mmHg vs. 103 mmHg, p < 0.001). This significance of difference was lost in vitamin D-insufficient athletes (106 mmHg vs. 103 mmHg, p = 0.12).
Significantly raised central systolic and diastolic blood pressure in vitamin D-insufficient elite athletes implicates vitamin D as a potential modifier of vascular functional health.
低维生素 D 水平与普通人群的血压升高有关。然而，前瞻性研究对维生素 D 补充的降压作用产生了相互矛盾的证据。心肺适应性可能调节维生素 D 与血压的关联。因此，我们在职业运动员中检查了这种关联，他们的高训练负荷是身体适应性的生物学对照。
检查了 50 名男性职业手球运动员（年龄 26±5 岁）。我们使用基于传递函数的分析，对手动脉搏动波进行了外周动脉波的分析，评估了中心主动脉压力参数。通过化学发光免疫测定法测定血清 25-羟维生素 D 浓度。将不足的阈值设定为<30ng/ml。
中心血压（cBP）为 98±7/60±10mmHg。主动脉脉搏波速度（PWV）为 6.3±1.0m/s。9 名运动员（18%）显示 25-羟维生素 D 水平不足，与 41 名（82%）25-羟维生素 D 水平充足的运动员相比，cBP 显著升高（106±5/68±8 比 97±7/58±9mmHg）（p<0.01）。维生素 D 充足的运动员的中心收缩压（cSBP）明显低于健康参考人群（97mmHg 比 103mmHg，p<0.001）。在维生素 D 不足的运动员中，这种差异的显著性丧失（106mmHg 比 103mmHg，p=0.12）。
维生素 D 不足的精英运动员中心收缩压和舒张压显著升高，表明维生素 D 可能是血管功能健康的潜在调节剂。
