Lehman T J, Hanson V, Singsen B H, Kornreich H K, Bernstein B, King K K
Arthritis Rheum. 1979 Sep;22(9):954-8. doi: 10.1002/art.1780220902.
Serum C3, C4 and total hemolytic complement (CH50) levels were measured for 21 children with systemic lupus erythematosus (SLE) and 81 first degree relatives. The mean serum C4 and CH50 levels of the 12 relatives with antinuclear antibodies (ANA( were depressed to levels equal to those of the index cases. A similar depression was not found for C3, nor was there a depression of C3, C4, or CH50 in the relatives without ANA. If preexistent depression of C4 levels can be documented in the ANA-positive relatives of index cases, it may provide an explanation for the inherited predisposition to SLE in some families.
对21名系统性红斑狼疮（SLE）患儿及其81名一级亲属测定了血清C3、C4和总溶血补体（CH50）水平。12名抗核抗体（ANA）阳性亲属的平均血清C4和CH50水平降至与指数病例相当的水平。未发现C3有类似降低情况，ANA阴性的亲属中C3、C4或CH50也未降低。如果能证实在指数病例的ANA阳性亲属中预先存在C4水平降低，这可能为某些家族中SLE的遗传易感性提供一种解释。
