Röther E, Lang B, Coldewey R, Hartung K, Peter H H
Department of Rheumatology and Clinical Immunology, University of Freiburg Medical Center, Germany.
Clin Rheumatol. 1993 Mar;12(1):31-5. doi: 10.1007/BF02231555.
In order to investigate, if complement levels can be used as an indicator of clinical activity in systemic lupus erythematosus (SLE), levels of C3, C4, CH50, and C3d were measured in 79 patients, 41 with inactive, 31 with moderately active and 7 with severely active disease. Our study shows that C3d, and particularly the C3d/C3 ratio, provide sensitive markers for disease activity in SLE. Since C3d is a direct measurement of complement turnover, it reflects complement activation better than C3, C4 and CH50.
为了研究补体水平是否可作为系统性红斑狼疮（SLE）临床活动的指标，我们对79例患者的C3、C4、CH50和C3d水平进行了检测，其中41例疾病不活动，31例中度活动，7例重度活动。我们的研究表明，C3d，尤其是C3d/C3比值，为SLE的疾病活动提供了敏感的标志物。由于C3d是补体转换的直接测量指标，它比C3、C4和CH50更能反映补体激活情况。
