来自 sp. NRRL S-1868 的两种细胞色素 P450 酶催化含色氨酸环二肽的不同二聚化。
Two Cytochrome P450 Enzymes from sp. NRRL S-1868 Catalyze Distinct Dimerization of Tryptophan-Containing Cyclodipeptides.
机构信息
Institut für Pharmazeutische Biologie und Biotechnologie, Philipps-Universität Marburg, Robert-Koch-Straße 4, 35037 Marburg, Germany.
出版信息
Org Lett. 2019 Sep 6;21(17):7094-7098. doi: 10.1021/acs.orglett.9b02666. Epub 2019 Aug 20.
Heterologous expression in and enzyme characterization proved that two P450 enzymes, AspB and NasB, from sp. NRRL S-1868 catalyze two new dimerization patterns of tryptophan-containing cyclodipeptides. Structure elucidation of the metabolites revealed an N1-C7' dimer of two cWP molecules as the predominant product of AspB and C3-C7' connected cWP with cWA as that of NasB.
异源表达和酶特征分析证明，来自 sp. NRRL S-1868 的两种 P450 酶 AspB 和 NasB 催化了含色氨酸环二肽的两种新的二聚化模式。代谢产物的结构阐明表明，AspB 的主要产物是两个 cWP 分子的 N1-C7'二聚体，而 NasB 的产物是 C3-C7'连接的 cWP 与 cWA。
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