Coupling of -l-Trp-l-Trp with Hypoxanthine Increases the Structure Diversity of Guanitrypmycins.

The -l-Trp-l-Trp (cWW, ) tailoring P450 GutD from was characterized by expression in , precursor feeding and enzyme assays. GutD catalyzes mainly the transfer of hypoxanthine to C2 and C3 of the indole ring of . cWW adducts with guanine were detected as minor products. An orthologous cluster was identified in These results expand the spectrum of cyclodipeptide derivatives by involvement of an additional nucleobase and identification of new coupling patterns.