两种茶树油制剂治疗慢性睑缘炎患者的疗效和安全性比较：一项双盲随机临床试验。
Comparison of Efficacy and Safety of Two Tea Tree Oil-Based Formulations in Patients with Chronic Blepharitis: A Double-Blinded Randomized Clinical Trial.
机构信息
Department of Ophthalmology, Ankara Numune Training and Research Hospital , Ankara, Turkey.
Department of Histology and Embryology, Ahi Evran University Faculty of Medicine , Kırşehir, Turkey.
出版信息
Ocul Immunol Inflamm. 2020 Aug 17;28(6):888-897. doi: 10.1080/09273948.2019.1644349. Epub 2019 Aug 20.
INTRODUCTION
It was aimed to evaluate the efficacy of two tea tree oil (TTO)-based cleansing gels in chronic blepharitis patients.
METHODS
Group-1 (basic gel containing 3%(w/w)-TTO) included 50 eyes of 25 patients and group-2 (advanced gel containing 3%(w/w)-TTO plus essential oils and vitamins) included 48 eyes of 24 patients. Ocular Surface Disease Index (OSDI), tear breakup time (TBUT), ocular surface staining pattern, Schirmer's test, impression cytology, Demodex presence and TNF-α, IL-6, IL-1β levels were evaluated at the first visit and 1 month after treatment.
RESULTS
In both groups, the mean OSDI score decreased (p1:0.001, p2:0.001), TBUT increased (p1:0.002, p2:0.004). In group-1, Demodex presence decreased from 42% to 27.8%; in group-2 from 54.2% to 20.6% (p1:0.302, p2:0.004). IL-1β and IL-6 decreased in group-2 (p1:0.002, p2:0.050). TNF-α decreased in both groups (p1:0.001, p2:0.001).
CONCLUSION
Both formulations improved ocular surface parameters. Group 2 showed more reduction in tear cytokines and Demodex count.
简介
本研究旨在评估两种茶树油（TTO）洁肤凝胶在慢性睑缘炎患者中的疗效。
方法
第 1 组（基础凝胶，含 3%（w/w）TTO）包括 25 例患者的 50 只眼，第 2 组（含 3%（w/w）TTO 及精油和维生素的高级凝胶）包括 24 例患者的 48 只眼。在首次就诊和治疗 1 个月后，评估眼表面疾病指数（OSDI）、泪膜破裂时间（TBUT）、眼表面染色模式、泪液分泌试验、印迹细胞学、蠕形螨存在情况以及 TNF-α、IL-6 和 IL-1β 水平。
结果
两组的 OSDI 评分均降低（p1：0.001，p2：0.001），TBUT 增加（p1：0.002，p2：0.004）。第 1 组中，蠕形螨的存在率从 42%降至 27.8%；第 2 组从 54.2%降至 20.6%（p1：0.302，p2：0.004）。第 2 组的 IL-1β 和 IL-6 降低（p1：0.002，p2：0.050）。两组的 TNF-α均降低（p1：0.001，p2：0.001）。
结论
两种配方均改善了眼表面参数。第 2 组泪液细胞因子和蠕形螨计数减少更明显。
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