National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University , Guangzhou , People's Republic of China.
Hackensack-Meridian Health Center for Discovery and Innovation , Nutley , NJ , USA.
Emerg Microbes Infect. 2019;8(1):1219-1222. doi: 10.1080/22221751.2019.1653795.
Plasmid-mediated antimicrobial resistance has emerged as one of the principal global issues, posing significant threats to public health. Herein, we reported a mobile tigecycline resistance mechanism Tet(X4) on both plasmid and chromosome in strains from migratory birds in China. Besides tigecycline, these (X4)-positive strains also exhibited elevated MICs to the FDA newly approved tetracycline antibiotics, eravacycline (4 µg/ml) and omadacycline (8 µg/ml). Worrisomely, the (X4)-carrying plasmids and chromosome also shared high homology with the plasmids from human. Taken together, Tet(X4) represents another emerging antimicrobial threat and collective efforts from different sectors are needed to control its further spread.
质粒介导的抗菌药物耐药性已成为一个主要的全球性问题，对公众健康构成重大威胁。在此，我们报道了来自中国候鸟中的 株，其质粒和染色体上均存在移动的替加环素耐药机制 Tet(X4)。除替加环素外，这些（X4）阳性株对 FDA 新批准的四环素类抗生素依拉环素（4 µg/ml）和奥马环素（8 µg/ml）的 MIC 也升高。令人担忧的是，携带 Tet(X4)的质粒和染色体与来自人类的质粒也具有高度同源性。总之，Tet(X4)代表了另一种新出现的抗菌药物威胁，需要不同部门共同努力控制其进一步传播。
