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2019 年 2 月,从中国四川和山东的猪肉中检测到质粒介导的替加环素耐药基因(X4)。

Detection of plasmid-mediated tigecycline-resistant gene (X4) in from pork, Sichuan and Shandong Provinces, China, February 2019.

机构信息

Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People's Republic of China, Beijing, People's Republic of China.

Food Safety Research Unit of Chinese Academy of Medical Sciences, China National Center for Food Safety Risk Assessment, Beijing, People's Republic of China.

出版信息

Euro Surveill. 2019 Jun;24(25). doi: 10.2807/1560-7917.ES.2019.24.25.1900340.

DOI:10.2807/1560-7917.ES.2019.24.25.1900340
PMID:31241040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6593906/
Abstract

The plasmid-mediated high-level tigecycline resistance gene, (X4), was detected in seven isolates from pork in two Chinese provinces. Two isolates belonged to the epidemic spreading sequence type ST101. (X4) was adjacent to IS and concurrent with in all seven isolates. In addition to IncFIB, the replicon IncFII was found to be linked to (X4). This report follows a recent detection of (X3)/(X4) in from animals and humans in China.

摘要

质粒介导的高水平替加环素耐药基因(X4)在来自中国两个省份猪肉中的 7 个分离株中被检测到。两个分离株属于流行传播的 ST101 序列型。(X4)位于 IS 附近,与所有 7 个分离株中的 同时存在。除 IncFIB 外,还发现(X4)与 IncFII 复制子相连。本报告是继最近在中国的动物和人类中检测到(X3)/(X4)之后的又一发现。

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本文引用的文献

1
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Nat Microbiol. 2019 Sep;4(9):1450-1456. doi: 10.1038/s41564-019-0445-2. Epub 2019 May 27.
2
ESBL- and AmpC-producing Escherichia coli from legally and illegally imported meat: Characterization of isolates brought into the EU from third countries.从合法和非法进口的肉类中分离出产 ESBL 和 AmpC 大肠杆菌:从第三国带入欧盟的分离株的特征。
Int J Food Microbiol. 2018 Oct 20;283:52-58. doi: 10.1016/j.ijfoodmicro.2018.06.009. Epub 2018 Jun 14.
3
New Variant of in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying and .
土耳其家禽和肉类样本中耐替加环素大肠杆菌的检测及全基因组分析
Poult Sci. 2025 Feb;104(2):104707. doi: 10.1016/j.psj.2024.104707. Epub 2024 Dec 20.
4
Distribution and spread of tigecycline resistance gene (X4) in from different sources.不同来源的 中替加环素耐药基因(X4)的分布和传播。
Front Cell Infect Microbiol. 2024 Jun 28;14:1399732. doi: 10.3389/fcimb.2024.1399732. eCollection 2024.
5
MALDI-TOF MS combined with AUC method for tigecycline susceptibility testing in .基质辅助激光解吸电离飞行时间质谱联用曲线下面积法用于替加环素药敏试验
JAC Antimicrob Resist. 2024 Mar 7;6(2):dlad119. doi: 10.1093/jacamr/dlad119. eCollection 2024 Apr.
6
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2021-2022.欧盟关于2021 - 2022年人类、动物和食品中动物源及指示性细菌的抗菌药物耐药性总结报告。
EFSA J. 2024 Feb 28;22(2):e8583. doi: 10.2903/j.efsa.2024.8583. eCollection 2024 Feb.
7
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8
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9
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EFSA J. 2023 Mar 6;21(3):e07867. doi: 10.2903/j.efsa.2023.7867. eCollection 2023 Mar.
10
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Microbiol Spectr. 2023 Jan 31;11(2):e0278622. doi: 10.1128/spectrum.02786-22.
一株携带 mcr-1 和 blaCTX-M-15 的广泛耐药性大肠杆菌临床分离株中的新型 。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01757-17. Print 2017 Dec.
4
Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant.携带 mcr-1 的质粒的遗传特征,描绘了黏菌素耐药决定因子传播的分子机制。
J Antimicrob Chemother. 2017 Feb;72(2):393-401. doi: 10.1093/jac/dkw411. Epub 2016 Sep 28.
5
Molecular Epidemiology and Genome Dynamics of New Delhi Metallo-β-Lactamase-Producing Extraintestinal Pathogenic Escherichia coli Strains from India.来自印度的产新型德里金属β-内酰胺酶的肠外致病性大肠杆菌菌株的分子流行病学与基因组动态
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6795-6805. doi: 10.1128/AAC.01345-16. Print 2016 Nov.
6
Within-host evolution of bacterial pathogens.细菌病原体的宿主体内进化
Nat Rev Microbiol. 2016 Mar;14(3):150-62. doi: 10.1038/nrmicro.2015.13. Epub 2016 Jan 19.
7
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Antimicrob Agents Chemother. 2015 Nov 23;60(2):789-96. doi: 10.1128/AAC.02465-15. Print 2016 Feb.
8
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9
Global trends in antimicrobial use in food animals.食用动物抗菌药物使用的全球趋势。
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5649-54. doi: 10.1073/pnas.1503141112. Epub 2015 Mar 19.