School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
School of Chemistry, University of New South Wales, Sydney, Australia.
Curr Protein Pept Sci. 2020;21(4):357-368. doi: 10.2174/1389203720666190820152508.
Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.
隐形眼镜的佩戴通常是安全的，并且能提供出色的视力。然而，隐形眼镜的佩戴常常与发生眼表面感染和炎症的风险相关，在严重的情况下，感染可能导致视力丧失。已经制造出了带抗菌肽涂层的隐形眼镜以帮助降低感染和炎症的发生率。本文综述了从构思、实验室和临床前试验到抗菌隐形眼镜最新临床试验信息的研究进展。我们提供了有关所遵循途径和遇到的陷阱的深入了解。这一过程并非总是线性或顺利的，但已经导致了一些带抗菌肽涂层的隐形眼镜在人类中的首批临床测试结果的发表。我们希望这有助于推动未来抗菌隐形眼镜的开发和商业化。
