Environmental Genomics and Systems Biology Research Group, Institute of Natural Resource Sciences (IUNR), Zurich University of Applied Sciences ZHAW, Wädenswil, Switzerland.
BMC Genomics. 2019 Aug 20;20(1):662. doi: 10.1186/s12864-019-6014-5.
The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not intrinsically better than the older technologies, although they are generally more efficient. In this correspondence, the importance for comparative genomics of additional manual assembly efforts over autoassembly and careful annotation is emphasized.
自从基因组测序出现以来，微生物基因组序列的质量一直是人们关注的焦点。基因组组装的质量取决于所使用的测序技术和生成序列的目的。虽然新型测序和生物信息学技术通常更高效，但它们并不一定比旧技术更好。在这封通信中，强调了在比较基因组学中，人工组装比自动组装和仔细注释更重要。
