Department of Otolaryngology, Beijing Anzhen Hospital, Capital Medical University, NO.2 Anzhen Road, Beijing, 100029, China.
Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, No. 2 Anzhen Road, Beijing, 100029, China.
Respir Res. 2019 Aug 20;20(1):188. doi: 10.1186/s12931-019-1143-6.
Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial dysfunction marker that may be linked to cardiovascular disease. We investigated to assess whether circulating ESM-1 levels are correlated with the presence of coronary artery disease (CAD) in patients with OSA.
We performed a cross-sectional study in 228 Chinese OSA subjects, including 185 patients with OSA and 43 controls. The Gensini stenosis scoring system was used to assess the severity of CAD. Circulating ESM-1 levels were measured by Human Magnetic Luminex Screening Assay. The associations between circulating ESM-1 levels and CAD were determined by multivariate logistic regression analysis. The association between ESM-1 levels and Gensini scores was determined by multivariate linear regression analysis.
CAD patients had significantly higher circulating ESM-1 levels compared with non-CAD patients (1279.01[918.52-1770.71] pg/ml vs 585.46[423.61-812.56] pg/ml, P < 0.001). After adjusting for confounding factors, we found that circulating ESM-1 levels were an independent risk factor for CAD (OR = 1.633/100 pg ESM-1, 95%CI =1.179-2.262, P = 0.003), while circulating ESM-1 levels have no significant correlation with the Gensini score. Furthermore, circulating ESM-1 showed higher discriminatory accuracy in predicting the presence of OSA (AUC:0.910).
Circulating ESM-1 might function as a useful biomarker for monitoring the development and progression of CAD in OSA patients.
内皮功能障碍是阻塞性睡眠呼吸暂停（OSA）患者动脉粥样硬化的最重要早期指标之一。内皮细胞特异性分子-1（ESM-1）是一种新型的内皮功能障碍标志物，可能与心血管疾病有关。我们研究了评估 OSA 患者循环 ESM-1 水平是否与冠状动脉疾病（CAD）的存在相关。
我们对 228 名中国 OSA 患者进行了横断面研究，包括 185 名 OSA 患者和 43 名对照。使用 Gensini 狭窄评分系统评估 CAD 的严重程度。通过人磁珠 Luminex 筛选测定法测定循环 ESM-1 水平。通过多元逻辑回归分析确定循环 ESM-1 水平与 CAD 的相关性。通过多元线性回归分析确定 ESM-1 水平与 Gensini 评分的相关性。
CAD 患者的循环 ESM-1 水平明显高于非 CAD 患者（1279.01[918.52-1770.71] pg/ml 与 585.46[423.61-812.56] pg/ml，P < 0.001）。在调整混杂因素后，我们发现循环 ESM-1 水平是 CAD 的独立危险因素（OR=1.633/100 pg ESM-1，95%CI=1.179-2.262，P=0.003），而循环 ESM-1 水平与 Gensini 评分无显著相关性。此外，循环 ESM-1 在预测 OSA 的存在方面具有更高的鉴别准确性（AUC：0.910）。
循环 ESM-1 可能是监测 OSA 患者 CAD 发生和进展的有用生物标志物。
