The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China; Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, National Clinical Research Center for Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, 100029, China; Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, 100029, China.
Sleep Med. 2022 Oct;98:114-120. doi: 10.1016/j.sleep.2022.06.015. Epub 2022 Jun 23.
There are increasing evidences for a direct relationship between the vascular system and obstructive sleep apnea (OSA). The aim of this study was to investigate the relationship between circulating endothelial cell specific molecule-1 (ESM-1), adhesion molecules and subclinical atherosclerosis in patients with OSA.
This was a cross-sectional study in which 161 patients with OSA and 56 controls were recruited. Demographic data, biochemical and polysomnography parameters were collected. We used a powerful high-throughput Multiplex Immunobead Assay technique to simultaneously test plasm levels of ESM-1, P-selectin, E-selectin, L-selectin, inter-cellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1). Carotid intima-media thickness (CIMT) were measured as parameters of vascular endothelial dysfunction and early atherosclerosis.
Increasing circulating levels of ESM-1, P-selectin, E-selectin, L-selectin, ICAM-1 and VCAM-1 were found increased in patients with OSA (all P < 0.001). Furthermore, OSA patients exhibited increased CIMT than controls (P < 0.05). Multivariate linear analysis indicated that elevated ESM-1, P-Selectin, E-selectin, and L-selectin levels were associated with AHI (all P < 0.05). Moreover, multivariate analysis showed that increasing ESM-1, VCAM-1, P-Selectin, and L-selectin were significantly associated with thick CIMT in OSA patients (all P < 0.05).
Increased circulating ESM-1 and adhesion molecules associated with thick CIMT in OSA, which is a marker of subclinical atherosclerosis. Strict attention to monitor circulating ESM-1 and adhesion molecules is necessary for early detection of subclinical atherosclerosis in OSA patients.
越来越多的证据表明血管系统与阻塞性睡眠呼吸暂停（OSA）之间存在直接关系。本研究旨在探讨 OSA 患者循环内皮细胞特异性分子-1（ESM-1）、黏附分子与亚临床动脉粥样硬化之间的关系。
这是一项横断面研究，共纳入 161 例 OSA 患者和 56 例对照者。收集人口统计学数据、生化和多导睡眠图参数。我们使用强大的高通量多重免疫珠测定技术同时检测 ESM-1、P 选择素、E 选择素、L 选择素、细胞间黏附分子 1（ICAM-1）和血管细胞黏附分子 1（VCAM-1）的血浆水平。颈动脉内膜中层厚度（CIMT）作为血管内皮功能障碍和早期动脉粥样硬化的参数进行测量。
我们发现 OSA 患者的循环 ESM-1、P 选择素、E 选择素、L 选择素、ICAM-1 和 VCAM-1 水平升高（均 P < 0.001）。此外，与对照组相比，OSA 患者的 CIMT 增加（P < 0.05）。多元线性分析表明，ESM-1、P-选择素、E 选择素和 L 选择素水平升高与 AHI 相关（均 P < 0.05）。此外，多元分析显示，OSA 患者中，ESM-1、VCAM-1、P-选择素和 L 选择素的增加与 CIMT 增厚显著相关（均 P < 0.05）。
在 OSA 中，循环 ESM-1 和黏附分子与 CIMT 增厚相关，CIMT 是亚临床动脉粥样硬化的标志物。密切关注监测循环 ESM-1 和黏附分子对于早期发现 OSA 患者的亚临床动脉粥样硬化是必要的。
