Roussel Marie-Pier, Morin Marika, Girardin Mélina, Fortin Anne-Marie, Leone Mario, Mathieu Jean, Gagnon Cynthia, Duchesne Elise
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, QC, Canada.
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires, Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean, Installations de Jonquière, Saguenay, QC, Canada.
BMC Res Notes. 2019 Aug 20;12(1):526. doi: 10.1186/s13104-019-4554-z.
The purpose of this side product of another unpublished research project, was to address the effects of a training program on skeletal muscle adaptations of people with myotonic dystrophy type 1 (DM1), under a multifaceted perspective. The objective of this study was to look at training induced muscular adaptations by evaluating changes in muscle strength, myofiber cross-sectional area (CSA), proportion of myofiber types and with indirect markers of muscle growth [proportion of centrally nucleated fibers (CNF) and density of neutrophils and macrophages]. Two men with DM1 underwent a 12-week strength/endurance training program (18 sessions). Two muscle biopsies were obtained pre- and post-training program.
Muscular adaptations occurred only in Patient 1, who attended 72% of the training sessions compared to 39% for Patient 2. These adaptations included increase in the CSA of type I and II myofibers and changes in their proportion. No changes were observed in the percentage of CNF, infiltration of neutrophils and macrophages and muscle strength. These results illustrate the capacity of skeletal muscle cells to undergo adaptations linked to muscle growth in DM1 patients. Also, these adaptations seem to be dependent on the attendance. Trial registration Clinicaltrials.gov NCT04001920 retrospectively registered on June 26th, 2019.
作为另一个未发表研究项目的附带产物，本研究旨在从多方面探讨一项训练计划对1型强直性肌营养不良症（DM1）患者骨骼肌适应性的影响。本研究的目的是通过评估肌肉力量、肌纤维横截面积（CSA）、肌纤维类型比例以及肌肉生长的间接标志物[中央核纤维（CNF）比例、中性粒细胞和巨噬细胞密度]的变化，来观察训练引起的肌肉适应性。两名DM1男性患者参加了为期12周的力量/耐力训练计划（共18节课程）。在训练计划前后分别进行了两次肌肉活检。
仅患者1出现了肌肉适应性变化，其参加了72%的训练课程，而患者2的参与率为39%。这些适应性变化包括I型和II型肌纤维CSA增加及其比例改变。CNF百分比、中性粒细胞和巨噬细胞浸润以及肌肉力量均未观察到变化。这些结果表明DM1患者骨骼肌细胞具有发生与肌肉生长相关适应性变化的能力。此外，这些适应性变化似乎取决于训练课程的参与度。试验注册：Clinicaltrials.gov NCT04001920，于2019年6月26日进行回顾性注册。
