Naeser P, Brolin S E, Eriksson U J
Department of Ophthalmology, University of Uppsala, Sweden.
Metabolism. 1988 Dec;37(12):1143-5. doi: 10.1016/0026-0495(88)90191-6.
Sorbitol concentration has been measured in retina, optic, and sural nerve of normal, diabetic, and aldose reductase inhibitor-treated diabetic rats. The sural nerve displayed significantly higher sorbitol content than the retina and the optic nerve both in control animals and in diabetic animals. In the sural nerve the response to treatment with an aldose reductase inhibitor was more marked than in the two other tissues. The activities of aldose reductase and sorbitol dehydrogenase were not influenced by diabetes. It is suggested that aldose reductase inhibition may be of greater use for alleviating peripheral nervous system accumulation of sorbitol than for hindering CNS accumulation of the polyol.
已对正常大鼠、糖尿病大鼠以及用醛糖还原酶抑制剂治疗的糖尿病大鼠的视网膜、视神经和腓肠神经中的山梨醇浓度进行了测量。在对照动物和糖尿病动物中，腓肠神经中的山梨醇含量均显著高于视网膜和视神经。在腓肠神经中，醛糖还原酶抑制剂治疗的反应比其他两个组织更为明显。糖尿病对醛糖还原酶和山梨醇脱氢酶的活性没有影响。有人提出，抑制醛糖还原酶对于减轻外周神经系统中山梨醇的蓄积可能比对阻止中枢神经系统中多元醇的蓄积更有用。
