Naeser P, Brolin S E, Berggren P O
Department of Ophthalmology, Uppsala University, Sweden.
Acta Ophthalmol (Copenh). 1987 Dec;65(6):693-8. doi: 10.1111/j.1755-3768.1987.tb07065.x.
Micromethods designed for studying the sorbitol shunt permitted studies of the retina and the optic nerve from mice. A significant accumulation of sorbitol was found in the retina of 5-months-old obese-hyper-glycaemic and severely STZ diabetic mice. The latter mice also showed increased sorbitol concentrations in the optic nerve. The activities of aldose reductase were about 3 times higher in the optic nerve than in the retina. Our findings show that not only the retina but also the optic nerve accumulates sorbitol. It is suggested that this hypothetically may lead to degeneration of the optic nerve in severe diabetes as in peripheral nerves.
用于研究山梨醇分流途径的微量方法可用于对小鼠视网膜和视神经进行研究。在5月龄肥胖-高血糖和严重链脲佐菌素诱导的糖尿病小鼠的视网膜中发现了大量山梨醇蓄积。后一组小鼠的视神经中山梨醇浓度也有所升高。醛糖还原酶的活性在视神经中比在视网膜中高约3倍。我们的研究结果表明，不仅视网膜，视神经也会蓄积山梨醇。据推测，这可能会导致严重糖尿病患者的视神经像周围神经一样发生退变。
