Ohshima Y, Beuth J, Ko H L, Roszkowski K, Hauck D, Pulverer G
Hygiene-Institut, Universität zu Köln.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Aug;269(2):251-6. doi: 10.1016/s0176-6724(88)80103-2.
Balb/c-mice were intravenously infected with 5 X 10(4) viable cells of Listeria monocytogenes SLCC 4013. Liver, lung and spleen of the animals showed heavy organ colonization 48 h after infection. Pretreatment of experimental animals with staphylococcal lipoteichoic acid (LTA; 2 mg i.p. 7 and 3 days before challenge) significantly reduced the bacterial count in these organs. In vitro, peritoneal macrophages from LTA-treated mice significantly reduced listerial viability as compared to control cells (p less than 0.0025). In vitro, exposure of macrophages from non-treated animals to LTA did not influence their bacterial killing ability.
将5×10⁴个产单核细胞李斯特菌SLCC 4013的活细胞静脉注射到Balb/c小鼠体内。感染48小时后，动物的肝脏、肺和脾脏出现严重的器官定植。用葡萄球菌脂磷壁酸（LTA；在攻击前7天和3天腹腔注射2毫克）对实验动物进行预处理，可显著降低这些器官中的细菌数量。在体外，与对照细胞相比，来自LTA处理小鼠的腹腔巨噬细胞显著降低了李斯特菌的活力（p<0.0025）。在体外，未处理动物的巨噬细胞暴露于LTA不会影响其细菌杀伤能力。
