Ohshima Y, Ko H L, Beuth J, Pulverer G
Institute of Hygiene, University of Cologne, Köln.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Nov;270(1-2):213-8. doi: 10.1016/s0176-6724(88)80156-1.
Immunostimulating and antineoplastic activities of staphylococcal lipoteichoic acid (LTA) were studied in Balb/c-mice. Systemic administration of LTA (1 mg or 2 mg i. p., 7 and 4 days prior to challenge) significantly enhanced chemiluminescence response of peritoneal macrophages (p less than 0.0125) and induced enlargement of the spleen (p less than 0.025) as compared to non-treated controls. In vivo the number of lung colonies was significantly lower (p less than 0.0125) in LTA-treated mice 14 days after challenge with L-1 sarcoma cells.
在Balb/c小鼠中研究了葡萄球菌脂磷壁酸（LTA）的免疫刺激和抗肿瘤活性。在攻击前7天和4天腹腔注射LTA（1毫克或2毫克）进行全身给药，与未处理的对照组相比，显著增强了腹腔巨噬细胞的化学发光反应（p<0.0125），并诱导脾脏肿大（p<0.025）。在体内，用L-1肉瘤细胞攻击14天后，LTA处理的小鼠肺集落数量显著减少（p<0.0125）。
