Goniolanceolatins A-H, Cytotoxic Bis-styryllactones from .

Eight new bis-styryllactones, goniolanceolatins A-H (-), possessing a rare α,β-unsaturated δ-lactone moiety with a (6)-configuration, were isolated from the CHCl extract of the stembark and roots of Miq., a plant endemic to Malaysia. Absolute structures were established through extensive 1D- and 2D-NMR data analysis, in combination with electronic dichroism (ECD) data. All of the isolates were evaluated for their cytotoxicity against human lung and colorectal cancer cell lines. Compounds and showed cytotoxicity, with IC values ranging from 2.3 to 4.2 μM, and were inactive toward human noncancerous lung and colorectal cells. Compounds , , , , and showed moderate to weak cytotoxicity. Docking studies of compounds and showed that they bind with EGFR tyrosine kinase and cyclin-dependent kinase 2 through hydrogen bonding interactions with the important amino acids, including Lys721, Met769, Asn818, Arg157, Ile10, and Glu12.