大苞楠中的高乃兰醇 A 和 B。
Goniolandrene A and B from Goniothalamus macrophyllus.
机构信息
MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan.
出版信息
Fitoterapia. 2013 Jul;88:1-6. doi: 10.1016/j.fitote.2013.03.028. Epub 2013 Apr 6.
Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compounds with two new compounds, namely goniolandrene-A (1), -B (2). The absolute configuration of goniolandrene B (2) was established by circular dichrosim. The compounds were cytotoxic against the P388 cells with IC50 values ranging from 0.42 to 160 μM. Goniothalamin (3) exhibited the highest inhibition of 0.42 μM.
厚鳞柯（Blume）Hook.f.和 Thoms.是一种广泛分布于马来西亚的植物。本研究的目的是从厚鳞柯的根部分离化合物。将粉碎的根用甲醇水溶液提取，然后依次用正己烷、氯仿和正丁醇萃取。从这些提取物中分离得到 6 种化合物，其中包括两种新化合物，即厚鳞柯烯-A（1）和-B（2）。通过圆二色性确定了厚鳞柯烯 B（2）的绝对构型。这些化合物对 P388 细胞具有细胞毒性，IC50 值范围为 0.42 至 160 μM。厚鳞柯素（3）的抑制作用最强，IC50 值为 0.42 μM。
Zotero 插件