Department of Obstetrics and Gynecology, Rambam Health Care Campus, and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel (R.L., R.L., A.R.).
Int J Gynecol Pathol. 2020 Jul;39(4):400-403. doi: 10.1097/PGP.0000000000000624.
A 67-yr-old female patient was diagnosed with squamous cell vulvar carcinoma and treated with a radical vulvectomy and bilateral sentinel lymphadenectomy. Three months after the surgery, the patient presented with local recurrence and underwent surgical excision of the mass, followed by chemotherapy. Eight months later, the patient was admitted due to weakness and pleural effusion. The patient underwent a chest computed tomography and echocardiogram, which revealed a large mass in the right ventricle penetrating into the pericardium and an additional mass residing on the tricuspid valve. She underwent a pericardial biopsy, and the pathology revealed a moderately differentiated squamous cell carcinoma metastasis. The patient was admitted thereafter in the oncological department for additional chemotherapy treatment. Because of a rapid deterioration in the patient's condition, only palliative treatment was given, and the patient died shortly after. Secondary cardiac tumors are very rare and have not been extensively studied in oncology. Therefore, optimal management is not entirely clear. It is extremely rare for vulvar cancer to metastasize to the heart, and only a handful of cases have been reported in the literature.
一位 67 岁女性患者被诊断患有鳞状细胞外阴癌，接受了根治性外阴切除术和双侧前哨淋巴结切除术。术后 3 个月，患者出现局部复发，接受了肿块切除术，并进行了化疗。8 个月后，患者因虚弱和胸腔积液入院。患者接受了胸部计算机断层扫描和超声心动图检查，显示右心室有一个大肿块穿透心包，还有一个肿块位于三尖瓣上。她接受了心包活检，病理显示为中分化鳞状细胞癌转移。此后，患者入住肿瘤科接受进一步的化疗治疗。由于患者病情迅速恶化，仅给予姑息治疗，患者随后不久死亡。心脏继发性肿瘤非常罕见，在肿瘤学领域尚未得到广泛研究。因此，其最佳治疗方法并不完全清楚。外阴癌转移到心脏极为罕见，文献中仅报道了少数几例。
