Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
From the Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD.
Dermatitis. 2021;32(2):124-130. doi: 10.1097/DER.0000000000000495.
Phenols and parabens (P&Ps) are commonly found in skin care products. However, P&Ps' role in pruritus and eczema has not been studied.
The aim of the study was to investigate the association between P&Ps, and pruritus and eczema.
This is a cross-sectional population-based study of 2202 participants. We examined the association between urinary phenols (triclosan, bisphenol A, benzophenone-3) and parabens (methyl and propyl parabens) and itchy rash/eczema using the 2005-2006 National Health and Nutrition Examination Survey database. Phenols and parabens were divided into quartiles (Qs) with the first Q as the reference. We calculated odds ratios and 95% confidence intervals, adjusting for multiple variables.
Urinary triclosan was inversely associated with itchy rash (P trend = 0.048). In a subpopulation analysis by race/ethnicity, urinary methyl paraben was positively associated with itchy rash in African Americans (fourth Q vs first Q: odds ratio, 12.60; 95% confidence interval, 1.03-154.06; P trend = 0.02). Triclosan was inversely associated with eczema in whites (P trend = 0.04).
Methyl paraben exposure may increase the risk of itchy rash in African Americans, whereas triclosan may decrease the risk of itchy rash and eczema. The potential effect of triclosan and methyl paraben in pruritus and eczema warrants further study.
酚类和对羟基苯甲酸酯（P&Ps）通常存在于护肤品中。然而，P&Ps 在瘙痒和湿疹中的作用尚未得到研究。
本研究旨在调查 P&Ps 与瘙痒和湿疹之间的关系。
这是一项基于人群的横断面研究，共有 2202 名参与者。我们使用 2005-2006 年全国健康和营养调查数据库，检查了尿液中酚类（三氯生、双酚 A、二苯甲酮-3）和对羟基苯甲酸酯（甲基和丙基对羟基苯甲酸酯）与瘙痒性皮疹/湿疹之间的关系。酚类和对羟基苯甲酸酯分为四分位数（Qs），第一 Q 作为参考。我们计算了比值比和 95%置信区间，并调整了多个变量。
尿液三氯生与瘙痒性皮疹呈负相关（P 趋势=0.048）。在按种族/民族进行的亚群分析中，尿液中甲基对羟基苯甲酸酯与非裔美国人的瘙痒性皮疹呈正相关（第四 Q 与第一 Q：比值比，12.60；95%置信区间，1.03-154.06；P 趋势=0.02）。三氯生与白人的湿疹呈负相关（P 趋势=0.04）。
甲基对羟基苯甲酸酯暴露可能会增加非裔美国人瘙痒性皮疹的风险，而三氯生可能会降低瘙痒性皮疹和湿疹的风险。三氯生和甲基对羟基苯甲酸酯在瘙痒和湿疹中的潜在作用需要进一步研究。
