Arfa-Fatollahkhani Paria, Safar Cherati Afsaneh, Habibi Seyed Amir Hasan, Shahidi Gholam Ali, Sohrabi Ahmad, Zamani Babak
Iran University of Medical Sciences, Tehran, Iran.
Golestan University of Medical Sciences and Health Services, Gorgan, Iran.
J Complement Integr Med. 2019 Aug 21;17(1):/j/jcim.2019.17.issue-1/jcim-2018-0245/jcim-2018-0245.xml. doi: 10.1515/jcim-2018-0245.
Background There is growing evidence that exercise modalities have considerable effects on Parkinson's disease (PD). This trial aimed to provide a more detailed viewpoint of short-term and long-term treadmill training (TT) effects on some motor and non-motor features of PD. Methods In this prospective, randomized, single-blind clinical trial, 20 mild to moderate PD patients, admitted in Rasoul-e-Akram hospital in Tehran, Iran, were randomly allocated in case (11) and control (9) groups. Treadmill intervention was performed at moderate intensity with 60% of heart rate reserved (HRR) in two 30-min sessions/week for a duration of 10 weeks. Both the groups were evaluated for three times; at the baseline, 2 months later and then 2 months after the second evaluation. We assigned the Timed Up and Go test (TUG), 6-min walk test (6MW), and the SF-8 healthy questionnaire, for assessment of balance, functional capacity, and Quality of life (QoL), respectively. Results Balance and functional capacity were significantly improved in the case group after the intervention (TUG p-value: 0.003, 6MW p-value: 0.003). Moreover, the long-term analysis revealed significant results as well (TUG p-value: 0.001, 6MW p-value: 0.004). Mental condition's scores of SF-8 in cases were not statistically different in short-term follow-up (F/U). However, analysis illustrated p-value: 0.016 for long-term assessment. The intervention induced significant changes in physical condition's scores in both of the F/Us (PC p-value: 0.013). Conclusions This study provides evidence that a TT of mild to moderate intensity has significant and persistent benefits for the balance, functional capacity, and QoL in PD.
背景 越来越多的证据表明，运动方式对帕金森病（PD）有相当大的影响。本试验旨在更详细地观察短期和长期跑步机训练（TT）对PD某些运动和非运动特征的影响。方法 在这项前瞻性、随机、单盲临床试验中，20例轻至中度PD患者被收治于伊朗德黑兰的拉苏勒-阿克拉姆医院，随机分为病例组（11例）和对照组（9例）。跑步机干预以中等强度进行，心率储备（HRR）的60%，每周两次，每次30分钟，持续10周。两组均进行三次评估，分别在基线时、2个月后以及第二次评估后2个月。我们分别采用定时起立行走测试（TUG）、6分钟步行测试（6MW）和SF-8健康问卷来评估平衡能力、功能能力和生活质量（QoL）。结果 干预后病例组的平衡能力和功能能力显著改善（TUG p值：0.003，6MW p值：0.003）。此外，长期分析也显示出显著结果（TUG p值：0.001，6MW p值：0.004）。病例组在短期随访中SF-8的心理状况评分无统计学差异。然而，长期评估的分析显示p值为0.016。干预在两次随访中均引起身体状况评分的显著变化（PC p值：0.013）。结论 本研究提供了证据，表明轻度至中度强度的跑步机训练对PD患者的平衡能力、功能能力和生活质量有显著且持久的益处。
