Department of Neurology, University of Ulm, Ulm, Germany.
Université de Strasbourg, Inserm, UMR-S1118, Strasbourg, France.
Mov Disord. 2019 Oct;34(10):1566-1570. doi: 10.1002/mds.27814. Epub 2019 Aug 21.
The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.
High-resolution T -weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.
The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, V = 921 ± 78 mm vs 30 non-PD, V = 917 ± 67 mm ; P = 0.850) and validated in a large cohort (202 PD, V = 925 ± 88 mm vs 100 non-PD, V = 932 ± 114 mm ; P = 0.602).
Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
下丘脑在帕金森病（PD）中的病理生理学机制尚不清楚。本研究的目的是定量研究 PD 患者的活体下丘脑体积。
使用 232 名 PD 患者和 130 名健康非 PD 个体的高分辨率 T1 加权磁共振成像（MRI）数据来量化下丘脑体积。
前瞻性采集的子队列（30 名 PD，V=921±78mm 与 30 名非 PD，V=917±67mm；P=0.850）和大队列（202 名 PD，V=925±88mm 与 100 名非 PD，V=932±114mm；P=0.602）的体积分析表明，PD 患者的下丘脑并未萎缩。
大量组织病理学证据表明 PD 患者下丘脑受累，但通过基于 MRI 的体积定量似乎无法检测到。
