免疫球蛋白 A 肾病能治愈吗？
A Role for IL-12 in IBD after All?
机构信息
Immunology Discovery, Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
Immunology Discovery, Janssen Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Immunity. 2019 Aug 20;51(2):209-211. doi: 10.1016/j.immuni.2019.07.008.
The interplay between intestinal epithelial barrier function, the intestinal microbiota, and cytokine signaling in the pathogenesis of inflammatory bowel disease is not completely understood. In this issue of Immunity, Eftychi et al. examined the cell types and cytokines that drive colitis in mice with an intestinal epithelial barrier defect and uncovered a surprising role for IL-12 in initiation of disease.
肠上皮屏障功能、肠道微生物群和细胞因子信号在炎症性肠病发病机制中的相互作用尚不完全清楚。在本期《免疫》中，Eftychi 等人研究了具有肠上皮屏障缺陷的小鼠中驱动结肠炎的细胞类型和细胞因子，并揭示了 IL-12 在疾病起始中的惊人作用。
Zotero 插件