在儿童期精神障碍的共同易感性中 的作用：一项基于人群的出生队列研究。
The Role of in Shared Susceptibility of Psychiatric Disorders during Childhood: A Population-Based Birth Cohort Study.
机构信息
Postgraduate Program In Health and Behavior, Catholic University of Pelotas., Pelotas, Rio Grande do Sul 96015-560, Brazil.
Laboratory of Clinical Neuroscience, Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul 96015-560, Brazil.
出版信息
Genes (Basel). 2019 Aug 20;10(8):626. doi: 10.3390/genes10080626.
BACKGROUND
It has been suggested that microRNAs (miRNAs; short non-protein-coding RNA molecules that mediate post-transcriptional regulation), including mir-9 and mir-34 families, are important for brain development. Current data suggest that mir-9 and mir-34 may have shared effects across psychiatric disorders. This study aims to explore the role of genetic polymorphisms in the (rs4916723) and (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort.
METHODS
Psychiatric disorders were assessed in 3585 individuals using Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria through the application of standard semi-structured interviews (using the Development and Well-Being Assessment, DAWBA) at the six-years-of-age follow-up. The outcome was defined as the presence of any mental disorder. We also considered two broad groups of internalizing and externalizing disorders to further investigate the role of these variants in mental health.
RESULTS
We observed an association between rs4916723 () and the presence of any psychiatric disorder (odds ratios (OR) = 0.820; 95% CI = 0.7130-0.944; = 0.006) and a suggestive effect on internalizing disorders (OR = 0.830; 95% CI = 0.698-0.987; = 0.035). rs4938723 () was not associated with any evaluated outcome.
CONCLUSION
The study suggests that may have an important role on a broad susceptibility for psychiatric disorders and may be important mainly for internalization problems.
背景
有人提出，微小 RNA（miRNAs；介导转录后调控的短非蛋白编码 RNA 分子），包括 mir-9 和 mir-34 家族，对大脑发育很重要。目前的数据表明，mir-9 和 mir-34 可能在精神障碍中具有共同作用。本研究旨在探讨基因多态性在 rs4916723 和 rs4938723 基因上的作用，这两个基因与儿童精神障碍的易感性有关，来自 2004 年佩洛塔斯出生队列研究。
方法
在 6 岁随访时，使用标准半结构化访谈（采用发展和福利评估，DAWBA），根据精神障碍诊断与统计手册，第四版（DSM-IV）标准，通过应用标准半结构化访谈（采用发展和福利评估，DAWBA），对 3585 个人进行了精神障碍评估。将精神障碍的存在作为结果。我们还考虑了两个广泛的内化和外化障碍组，以进一步研究这些变体在心理健康中的作用。
结果
我们观察到 rs4916723 （）与任何精神障碍的存在之间存在关联（比值比（OR）=0.820；95%可信区间（CI）=0.7130-0.944；=0.006），并且对内化障碍具有提示作用（OR=0.830；95%可信区间（CI）=0.698-0.987；=0.035）。rs4938723 （）与任何评估结果无关。
结论
该研究表明，可能在广泛的精神障碍易感性方面发挥重要作用，并且可能主要对内化问题很重要。
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