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影响范围:考虑塑造微生物毒力的复杂突变过程。

mSphere of Influence: Considering Complex Mutational Processes That Shape Microbial Virulence.

机构信息

Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.

出版信息

mSphere. 2019 Aug 21;4(4):e00578-19. doi: 10.1128/mSphere.00578-19.

Abstract

Matt Anderson works in the field of genetics and infectious disease, with a focus on the human fungal pathogen In this mSphere of Influence article, he reflects on how two papers, "Gene Flow Contributes to Diversification of the Major Fungal Pathogen " (J. Ropars, C. Maufrais, D. Diogo, M. Marcet-Houben, A. Perin, et al., Nat Commun 9:2253, 2018, https://doi.org/10.1038/s41467-018-04787-4) and "Selection of Trisomy during Oropharyngeal Infection Results in a Commensal-Like Phenotype" (A. Forche, N. V. Solis, M. Swidergall, R. Thomas, A. Guyer, et al., PLoS Genet 15:e1008137, 2019, https://doi.org/10.1371/journal.pgen.1008137), made an impact on him by incorporating less commonly investigated mechanisms of genome evolution into the context of microbial adaptation.

摘要

马特·安德森(Matt Anderson)从事遗传学和传染病领域的工作,专注于人类真菌病原体。在这篇 mSphere 影响文章中,他反思了两篇论文,“基因流有助于主要真菌病原体的多样化”(J. Ropars,C. Maufrais,D. Diogo,M. Marcet-Houben,A. Perin,等,Nat Commun 9:2253,2018,https://doi.org/10.1038/s41467-018-04787-4)和“口咽感染过程中选择三体导致类似共生的表型”(A. Forche,N. V. Solis,M. Swidergall,R. Thomas,A. Guyer,等,PLoS Genet 15:e1008137,2019,https://doi.org/10.1371/journal.pgen.1008137),如何将较少研究的基因组进化机制纳入微生物适应的背景中,对他产生了影响。

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