Abdel Gader Abdel Galil M, Al-Ghumlas Abeer K, Al Momen Abdul Kareem M, Awadalla Sitel Banat A, Badri Motasim
Department of Basic Medical Science, The Blood Bank, King Khalid University Hospital, King Saud University, Riyadh, KSA.
Department of Basic Medical Science, College of Medicine, Riyadh, KSA.
J Taibah Univ Med Sci. 2017 Jun 9;12(5):437-444. doi: 10.1016/j.jtumed.2017.04.001. eCollection 2017 Oct.
There is universal concern about the inappropriate use of fresh frozen plasma (FFP). This study aimed to determine the extent of the inappropriate use of FFP at a university hospital in KSA.
Medical records on the annual use of FFP were analysed from 1986 to 2007. Then, the results of the coagulation screening tests were extracted from the medical records of 531 consecutive patients in various departments of the hospital.
As many as 68,480 FFP units were used during the 22 year study period. Consumption increased and then plateaued in 1995, but dropped dramatically by 30.9% and reached its lowest level in 2000. There was also a concomitant and overlapping drop in both FFP usage and the hospital mortality rate per patient admission. One-thousand-six-hundred-twenty FFP units were issued for 531 patients. Coagulation testing, before and after infusion, was adopted in almost all patients in the Department of Obstetrics and Gynaecology, in 90% of patients in the Department of Surgery and in approximately 70% of patients in other departments.
Significant inappropriate use of FFP at our institute has been made evident by examining the remarkable drop in use following the universal "HIV scare" of the early 1990s. The resulting drop in the hospital mortality rate, accompanying the simultaneous drop in FFP use, reflects the benefits of resorting to the use of less blood therapy. Coagulation testing was used to a satisfactory extent. Transfusion audits and educational programs could result a better use of FFP.
新鲜冰冻血浆（FFP）的不当使用受到广泛关注。本研究旨在确定沙特阿拉伯一所大学医院FFP的不当使用程度。
分析了1986年至2007年FFP年度使用的医疗记录。然后，从该医院各科室531例连续患者的医疗记录中提取凝血筛查试验结果。
在22年的研究期间，共使用了68480单位的FFP。消耗量在1995年增加，随后趋于平稳，但在2000年急剧下降了30.9%，达到最低水平。FFP使用量和每例患者入院时的医院死亡率也同时出现了重叠下降。为531例患者发放了1620单位的FFP。几乎所有妇产科患者、90%的外科患者以及约70%的其他科室患者在输注前后都进行了凝血检测。
通过检查20世纪90年代初普遍的“艾滋病恐慌”后使用量的显著下降，我们研究所FFP的大量不当使用已显而易见。FFP使用量同时下降，医院死亡率也随之下降，这反映了采用较少血液治疗的益处。凝血检测的使用程度令人满意。输血审核和教育项目可能会使FFP得到更好的使用。
