补充蜂蜜对绝经后乳腺癌患者安全性指标的影响。
Effects of honey supplementation on safety profiles among postmenopausal breast cancer patients.
作者信息
Zakaria Zaida, Zainal Abidin Zairos F, Gan Siew H, Wan Abdul Hamid Wan Z, Mohamed Mahaneem
机构信息
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
出版信息
J Taibah Univ Med Sci. 2018 Aug 25;13(6):535-540. doi: 10.1016/j.jtumed.2018.04.013. eCollection 2018 Dec.
OBJECTIVES
In this study, we aimed to determine the effect of honey supplementation on the safety profiles of postmenopausal breast cancer patients.
METHODS
Seventy-two postmenopausal women with stage I, II, or III breast cancer from the Oncology Clinic, Universiti Sains Malaysia Hospital were treated with anastrozole (1 mg/day). Patients were randomly assigned to one of the two groups (n = 36/group): a control group (no honey) and a honey group (20 g/day of honey for 12 weeks). Fasting blood samples were obtained pre- and post-intervention to investigate differences in the haematological, renal, and liver profiles of patients in both the groups.
RESULTS
Post-intervention, alanine aminotransferase levels were significantly higher in the control group than in the honey group. In the honey group, white blood cell counts, platelet counts, and creatinine levels were significantly higher following honey supplementation for 12 weeks. Nevertheless, the values were still within normal ranges.
CONCLUSIONS
The present study suggests that honey supplementation of 20 g/day for 12 weeks is safe and beneficial for postmenopausal breast cancer patients.
目的
在本研究中，我们旨在确定补充蜂蜜对绝经后乳腺癌患者安全性的影响。
方法
来自马来西亚理科大学医院肿瘤诊所的72名I、II或III期绝经后乳腺癌女性患者接受阿那曲唑（1毫克/天）治疗。患者被随机分为两组（每组n = 36）：对照组（不服用蜂蜜）和蜂蜜组（每天服用20克蜂蜜，持续12周）。在干预前后采集空腹血样，以研究两组患者血液学、肾脏和肝脏指标的差异。
结果
干预后，对照组的丙氨酸转氨酶水平显著高于蜂蜜组。在蜂蜜组中，补充蜂蜜12周后白细胞计数、血小板计数和肌酐水平显著升高。然而，这些值仍在正常范围内。
结论
本研究表明，每天补充20克蜂蜜，持续12周，对绝经后乳腺癌患者是安全且有益的。
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