Ghazali Wan Syaheedah Wan, Romli Aminah Che, Mohamed Mahaneem
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
BMC Complement Altern Med. 2017 Mar 28;17(1):175. doi: 10.1186/s12906-017-1703-6.
Honey has been demonstrated to possess anti-inflammatory property. This is a randomized, controlled, open-label trial to determine the effects of 12-week honey oral supplementation on plasma inflammatory markers such as high sensitive C-reactive protein, interleukin-6 and tumor necrosis factor-α among chronic smokers.
METHODS/DESIGN: A total of 32 non-smokers and 64 chronic smokers from Quit Smoking Clinic and Health Campus, Universiti Sains Malaysia participated in the study. Smokers were then randomized into 2 groups: smokers with honey group that received Malaysian Tualang honey (20 g/day daily for 12 weeks) and smokers without honey group. Blood was obtained from non-smokers and smokers at pre-intervention, and from smokers at post-intervention for measurement of the inflammatory markers.
At pre-intervention, smokers had significantly higher high sensitive C-reactive protein than non-smokers. In smokers with honey group, tumor necrosis factor-α was significantly increased while high sensitive C-reactive protein was significantly reduced at post-intervention than at pre-intervention.
This study suggests that honey supplementation has opposite effects on tumor necrosis factor-α and high sensitive C-reactive protein indicating the inconclusive effect of honey on inflammation among chronic smokers which needs further study on other inflammatory markers.
The Trial has been registered in the Australian New Zealand Clinical Trials Registry: ACTRN12615001236583 . Registered 11 November 2015 (Retrospectively Registered).
蜂蜜已被证明具有抗炎特性。这是一项随机、对照、开放标签试验，旨在确定在慢性吸烟者中，为期12周的蜂蜜口服补充剂对血浆炎症标志物（如高敏C反应蛋白、白细胞介素-6和肿瘤坏死因子-α）的影响。
方法/设计：来自马来西亚理科大学戒烟诊所和健康校园的32名非吸烟者和64名慢性吸烟者参与了该研究。吸烟者随后被随机分为两组：蜂蜜组吸烟者接受马来西亚特浪蜂蜜（每天20克，持续12周）和无蜂蜜组吸烟者。在干预前从非吸烟者和吸烟者中采集血液，并在干预后从吸烟者中采集血液以测量炎症标志物。
在干预前，吸烟者的高敏C反应蛋白显著高于非吸烟者。在蜂蜜组吸烟者中，干预后肿瘤坏死因子-α显著增加，而高敏C反应蛋白显著低于干预前。
本研究表明，补充蜂蜜对肿瘤坏死因子-α和高敏C反应蛋白有相反的影响，这表明蜂蜜对慢性吸烟者炎症的影响尚无定论，需要对其他炎症标志物进行进一步研究。
该试验已在澳大利亚新西兰临床试验注册中心注册：ACTRN12615001236583。于2015年11月11日注册（追溯注册）。
