Heller A J, Ring H A, Reynolds E H
University Department of Neurology, King's College Hospital, London, U.K.
Epilepsy Res. 1988 Jul-Aug;2(4):276-80. doi: 10.1016/0920-1211(88)90020-4.
Twenty-five out of 41 (61%) patients with drug-resistant complex partial seizures showed an initial dramatic response to clobazam. Sixteen of these responders developed tolerance to the effects of clobazam so that only 9 (22%) maintained a dramatic response for 1 year. Factors which appeared important in predicting a dramatic response to treatment were a known aetiology for the epilepsy, the occurrence of complex partial seizures alone (i.e., without secondary generalisation) and the absence of mental retardation.
41例耐药性复杂部分性癫痫患者中有25例（61%）对氯巴占最初有显著反应。其中16例反应者对氯巴占的效果产生了耐受性，以至于只有9例（22%）在1年内维持显著反应。在预测治疗显著反应方面似乎重要的因素包括癫痫已知病因、仅发生复杂部分性发作（即无继发性全面发作）以及无智力发育迟缓。
