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Comparative in vitro activity of the new oxacephem antibiotic, flomoxef (6315-S).

作者信息

Ruckdeschel G, Eder W

机构信息

Max von Pettenkofer-Institute for Hygiene and Medical Microbiology, Klinikum Grosshadern, University of Munich, FRG.

出版信息

Eur J Clin Microbiol Infect Dis. 1988 Oct;7(5):687-91. doi: 10.1007/BF01964256.

DOI:10.1007/BF01964256
PMID:3143586
Abstract

The in vitro activity of flomoxef (6315-S) was determined and compared to that of different cephalosporins against 787 clinical isolates of staphylococci, Enterobacteriaceae and anaerobes. Flomoxef is similar in activity to latamoxef and cefotaxime against Enterobacteriaceae, slightly more active than cephalothin and cefamandole against oxacillin-sensitive strains of Staphylococcus aureus and minimally less active than cefamandole against oxacillin-resistant strains. Flomoxef showed similar or better activity than latamoxef and cefoxitin against most of the anaerobic species of medical importance.

摘要

相似文献

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Comparative in vitro activity of the new oxacephem antibiotic, flomoxef (6315-S).
Eur J Clin Microbiol Infect Dis. 1988 Oct;7(5):687-91. doi: 10.1007/BF01964256.
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In vitro activity and stability against novel beta-lactamases of investigational beta-lactams (cefepime, cefpirome, flomoxef, SCE2787 and piperacillin plus tazobactam) in comparison with established compounds (cefotaxime, latamoxef and piperacillin).与已上市化合物(头孢噻肟、拉氧头孢和哌拉西林)相比,研究中的β-内酰胺类药物(头孢吡肟、头孢匹罗、氟氧头孢、SCE2787和哌拉西林加他唑巴坦)对新型β-内酰胺酶的体外活性和稳定性。
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Am J Clin Pathol. 1979 Nov;72(5):858-60. doi: 10.1093/ajcp/72.5.858.

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本文引用的文献

1
Production of low-affinity penicillin-binding protein by low- and high-resistance groups of methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌低抗性组和高抗性组产生低亲和力青霉素结合蛋白。
Antimicrob Agents Chemother. 1987 Sep;31(9):1307-11. doi: 10.1128/AAC.31.9.1307.
2
In vitro activity and beta-lactamase stability of a new difluoro oxacephem, 6315-S.新型二氟氧头孢烯6315-S的体外活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1986 Nov;30(5):638-44. doi: 10.1128/AAC.30.5.638.