莫西拉酸（LY127935），一种新型半合成1-氧杂-β-内酰胺抗生素，具有显著的抗菌活性：与头孢孟多和妥布霉素的体外比较。
Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.
作者信息
Jones R N, Fuchs P C, Sommers H M, Gavan T L, Barry A L, Gerlach E H
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):750-6. doi: 10.1128/AAC.17.4.750.
Abstract
Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin greater than moxalactam; for streptococci, cefamandole greater than moxalactam greater than tobramycin; and for Pseudomonas aeruginosa, tobramycin greater than moxalactam greater than cefamandole. Moxalactam also demonstrated significant activity against the Bacteroides fragilis group and other anaerobes. Moxalactam was comparable to cefotaxime (HR756) in its inhibition of cephalothin-resistant and aminoglycoside-resistant clinical isolates.
摘要
羟羧氧酰胺菌素（LY127935）在体外对肠杆菌科细菌、嗜水气单胞菌和嗜麦芽窄食单胞菌的临床分离株显示出比头孢孟多和妥布霉素更强的活性。这三种药物对其他微生物的活性如下：对于葡萄球菌，头孢孟多 = 妥布霉素＞羟羧氧酰胺菌素；对于链球菌，头孢孟多＞羟羧氧酰胺菌素＞妥布霉素；对于铜绿假单胞菌，妥布霉素＞羟羧氧酰胺菌素＞头孢孟多。羟羧氧酰胺菌素对脆弱拟杆菌群和其他厌氧菌也表现出显著活性。羟羧氧酰胺菌素在抑制对头孢噻吩耐药和对氨基糖苷类耐药的临床分离株方面与头孢噻肟（HR756）相当。
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