Zhang Hongtao, Dev Devjoy, Yu Huimin, Di Xuemin, Liang Yansong, Zhang Lijuan, Liu Xiaoli, Zhao Jinxin, Liu Zezhou, Sui Aixia, Wang Juan, Hu Man
Department of Oncology, The Hebei General Hospital, Shijiazhuang, China.
Department of Bioengineering, Imperial College London, South Kensington, London, United Kingdom.
J Cancer Res Ther. 2019;15(4):793-800. doi: 10.4103/jcrt.JCRT_347_18.
The objective of the study is to test whether three-dimensional (3D)-printed template can be used reproducibly for guiding malignant tumors brachytherapy and study the dosimetric consistency and adequacy between pre- and post-plan.
Between January and December 2016 in our hospital, a total of 14 patients underwent 3D-printed template-guided brachytherapy. All the patients were fixed into position using a vacuum cushion before undertaking a computed tomography (CT) scan. After the preplan was designed, the templates were printed. The tumors were punctured through predesigned needle holes. Following this, another CT scan was used to confirm the locations of needles, and then the I radioactive seeds were implanted into the tumor according to the preplan. Postplan was performed after the operation. Data of the D90 (minimum absorbed dose of 90% target volume), V90 (90% prescription dose coverage volume percentage of target volume), V100, V150, and seed number pre- and post-operation were collected and compared.
The mean D90, V90, V100, V150, and seed number preoperation were 94.96 ± 16.43 Gy, 94.64% ± 1.43%, 91.21% ± 1.59%, 65.01% ± 5.78%, and 46.67 ± 21.87, respectively. The mean D90, V90, V100, V150, and seed number postoperation were 91.97 ± 17.54 Gy, 93.35% ± 2.45%, 89.35% ± 3.21%, 63.40% ± 6.36%, and 46.60 ± 22.85, respectively. No significant difference between pre- and post-operation was observed across the data (P >0.05).
For immobilized malignant tumors, 3D-printed template can be used reproducibly. The dose parameters in preplan can be achieved easily and satisfactorily by 3D-printed template guided brachytherapy, and it may become an easily reproducible standardized procedure in the future.
本研究旨在测试三维（3D）打印模板是否可重复用于引导恶性肿瘤近距离放射治疗，并研究计划前和计划后剂量测定的一致性和充分性。
2016年1月至12月期间，我院共有14例患者接受了3D打印模板引导的近距离放射治疗。所有患者在进行计算机断层扫描（CT）前均使用真空垫固定体位。设计预计划后，打印模板。通过预先设计的针孔对肿瘤进行穿刺。在此之后，使用另一次CT扫描确认针的位置，然后根据预计划将I放射性种子植入肿瘤。术后进行后计划。收集并比较手术前后D90（90%靶体积的最小吸收剂量）、V90（靶体积的90%处方剂量覆盖体积百分比）、V100、V150和种子数量的数据。
术前D90、V90、V100、V150和种子数量的平均值分别为94.96±16.43 Gy、94.64%±1.43%、91.21%±1.59%、65.01%±5.78%和46.67±21.87。术后D90、V90、V100、V150和种子数量的平均值分别为91.97±17.54 Gy、93.35%±2.45%、89.35%±3.21%、63.40%±6.36%和46.60±22.85。各数据在手术前后均未观察到显著差异（P>0.05）。
对于固定的恶性肿瘤，3D打印模板可重复使用。通过3D打印模板引导的近距离放射治疗可以轻松且令人满意地实现预计划中的剂量参数，并且在未来它可能成为一种易于重复的标准化程序。
