Zhao Guang Sheng, Liu Song, Liu Hua, Lv Wen Cai, Yang Liang, Li Chuang, Zhou Jun, Wang Ruo Yu, Song Yong Chun
Cancer Treatment Center, Affiliated Zhongshan Hospital of Dalian University, No.6 Jie Fang Street, Dalian, 116001, Liaoning Province, China.
Interventional Medicine Center, Linyi Cancer Hospital, 6 East Lingyuan Street, Linyi, 276001, Shandong Province, China.
Sci Rep. 2022 Mar 8;12(1):3731. doi: 10.1038/s41598-022-07729-9.
To observe the safety and efficacy of CT-guided 3D template-assisted radioactive I seed implantation in the treatment of unresectable advanced soft tissue sarcoma (STS). Sixty-two patients who underwent continuous 3D template-assisted radioactive I seed implantation for the treatment of unresectable advanced STS from August 2017 to August 2018 were selected from four tumor treatment centers for retrospective analysis. The postoperative adverse reactions and tumor response were recorded, and the postoperative complications were observed and treated at the same time. The overall survival (OS) rate was determined. All patients successfully completed I seed implantation. In practice, the median number of puncture needles used during the operation was 20, and the median number of I particles was 88. There were no statistical differences in the relative dosimetry parameters before and after the operation (P > 0.05). Tumor evaluation was performed 6 months after the operation. The effective rate was 61.3%, and the local control rate was 93.5%. As of March 2020, the 1-year survival rate was 85.2%, and the 2-year survival rate was 49.0%. The OS was 23 months. CT-guided 3D template-assisted I seed implantation for the treatment of unresectable STS has a high local control rate, thereby further prolonging the OS of patients with unresectable STS.
观察CT引导下三维模板辅助放射性碘籽源植入治疗不可切除的晚期软组织肉瘤（STS）的安全性和有效性。从四个肿瘤治疗中心选取2017年8月至2018年8月期间接受连续三维模板辅助放射性碘籽源植入治疗不可切除晚期STS的62例患者进行回顾性分析。记录术后不良反应及肿瘤反应，同时观察和处理术后并发症。确定总生存（OS）率。所有患者均成功完成碘籽源植入。实际操作中，术中穿刺针数中位数为20根，碘粒子数中位数为88个。术后相对剂量学参数差异无统计学意义（P＞0.05）。术后6个月进行肿瘤评估。有效率为61.3%，局部控制率为93.5%。截至2020年3月，1年生存率为85.2%，2年生存率为49.0%。OS为23个月。CT引导下三维模板辅助碘籽源植入治疗不可切除的STS具有较高的局部控制率，从而进一步延长了不可切除STS患者的OS。
