短小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响。一项为期28天的序贯研究。II. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性及迟发型超敏皮肤反应的变化。
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.
作者信息
Thatcher N, Swindell R, Crowther D
出版信息
Clin Exp Immunol. 1979 Feb;35(2):171-9.
Abstract
C. parvum and BCG produced significant changes in NK, K and T cell lymphocytotoxicity using a Chang liver target cell. A consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. This was particularly marked for C. parvum and 'K' cell activity. Skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. The importance of using lymphocyte concentration-cytotoxicity titration curves and the linearization of such curves is discussed. An immunotherapy schedule with 3 weekly immunization intervals is proposed as the optimum schedule in patients receiving C. parvum at a dose of 2.0 mg/m2 i.v.
摘要
使用张氏肝靶细胞，微小隐孢子虫和卡介苗在自然杀伤细胞、杀伤细胞和T细胞淋巴细胞毒性方面产生了显著变化。描述了在28天内早期抑制、恢复、超调然后下降的一致时间模式。微小隐孢子虫和“杀伤”细胞活性尤为明显。28天时对回忆抗原的皮肤试验反应性与免疫前反应性没有明显差异。讨论了使用淋巴细胞浓度-细胞毒性滴定曲线以及此类曲线线性化的重要性。对于接受静脉注射剂量为2.0mg/m²微小隐孢子虫的患者，建议每3周进行一次免疫治疗的方案为最佳方案。
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Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.短小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响。一项为期28天的序贯研究。II. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性及迟发型超敏皮肤反应的变化。
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本文引用的文献
1
Cytotoxic lymphocytes from rats depleted of thymus processed cells.来自胸腺处理细胞耗竭的大鼠的细胞毒性淋巴细胞。
Nat New Biol. 1971 Jul 21;232(29):80-2. doi: 10.1038/newbio232080a0.
2
Antibody in the induction and inhibition of lymphocyte cytotoxicity.抗体在淋巴细胞细胞毒性的诱导和抑制中的作用。
Transplant Rev. 1972;13:67-90. doi: 10.1111/j.1600-065x.1972.tb00060.x.
3
The cytotoxic activity of lymphocytes from human lymph in vitro.人淋巴细胞在体外的细胞毒性活性。
Clin Exp Immunol. 1974 Jul;17(3):361-9.
4
5
6
Inhibition of antibody-dependent cellular cytotoxicity and immunoglobulin synthesis by an antiserum prepared against a human B-cell Ia-like molecule.针对人B细胞Ia样分子制备的抗血清对抗体依赖性细胞毒性和免疫球蛋白合成的抑制作用。
J Exp Med. 1976 Jul 1;144(1):113-22. doi: 10.1084/jem.144.1.113.
7
Characterization of mononuclear effector cells in human blood.人血中单核效应细胞的特性分析
Clin Exp Immunol. 1976 Jan;23(1):104-13.
8
Changes in cellular immunity following nephrectomy for localized and metastatic hypernephroma.局限性和转移性肾细胞癌肾切除术后细胞免疫的变化。
Eur J Cancer (1965). 1977 Sep;13(9):951-6. doi: 10.1016/0014-2964(77)90171-2.
9
Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations.人类B淋巴细胞和T淋巴细胞的表面标志物。VI. 对细胞系的细胞毒性作为淋巴细胞亚群的功能标志物。
Int J Cancer. 1975 Apr 15;15(4):596-605. doi: 10.1002/ijc.2910150409.
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