School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.
School of Chemistry, Sun Yat-sen University, Guangzhou, People's Republic of China.
Nat Prod Res. 2021 May;35(9):1497-1503. doi: 10.1080/14786419.2019.1655416. Epub 2019 Aug 22.
A preliminary research on the marine fungus sp. XBB-9 resulted in a pair of novel bisindole alkaloid enantiomers, (+)- and (-)-fusaspoid A (/) and 12 diverse compounds. One strain many compound (OSMAC) method was used to enhance as many biosynthetic pathways as possible. The structures of the compounds were elucidated by spectroscopic analysis, and the absolute configuration of was determined by X-ray single-crystal diffraction analysis. Compounds and were tested for cytotoxic activity against HCT-15, RKO cell lines, but were inactive. Compounds and were the first example of bisindole alkaloids isolated from fungus sp. XBB-9.
初步研究海洋真菌 XBB-9 产生了一对新型的双吲哚生物碱对映异构体(+)-和(-)-fusaspoid A (/ )和 12 种不同的化合物。采用一种菌株多种化合物 (OSMAC) 方法尽可能多地增强生物合成途径。通过光谱分析阐明了化合物的结构，通过 X 射线单晶衍射分析确定了 的绝对构型。测试了化合物 和 对 HCT-15、RKO 细胞系的细胞毒性活性，但均无活性。化合物 和 是首次从真菌 XBB-9 中分离得到的双吲哚生物碱。
