Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Histology, Tanta University, Tanta, Egypt.
J Dermatolog Treat. 2021 Jun;32(4):383-390. doi: 10.1080/09546634.2019.1658860. Epub 2019 Sep 4.
Vitiligo is a chronic cutaneous disease characterized with hypopigmented patches that leave psychological impact on the patients. There is increasing need for new treatment modalities to shorten the duration of treatment of vitiligo with the least side effects.
To explore the effect of intralesional injection of prostaglandin F2α on the outcome of narrow band ultraviolet rays B (NBUVB) for patients with stable vitiligo.
The study included 27 stable vitiligo patients with overall symmetrical lesions. For each patient, one patch was treated with NBUVB alone (control side), while another symmetrical patch was treated with combined intralesional injection of prostaglandin F2α with NBUVB therapy, weekly for 3 months.
There was statistically significant improvement in the repigmentation in the combination group compared with NBUVB group. Side effects were minimal.
Intralesional injection of prostaglandin F2α in combination with NBUVB therapy could be considered as safe and tolerable technique for treatment of vitiligo, it shortens the duration of NBUVB therapy. Longer follow up is needed.
白癜风是一种慢性皮肤病，其特征是色素减退斑块，会给患者带来心理影响。人们越来越需要新的治疗方法，以缩短白癜风的治疗时间，同时尽量减少副作用。
探讨前列腺素 F2α 皮损内注射对窄带紫外线 B（NBUVB）治疗稳定期白癜风患者疗效的影响。
本研究纳入 27 例整体对称皮损的稳定期白癜风患者。每位患者一侧皮损接受 NBUVB 单独治疗（对照组），另一侧皮损接受前列腺素 F2α 皮损内注射联合 NBUVB 治疗，每周 1 次，共 3 个月。
联合组的复色情况明显优于 NBUVB 组，差异有统计学意义。副作用极小。
前列腺素 F2α 皮损内注射联合 NBUVB 治疗可作为一种安全耐受的白癜风治疗技术，可缩短 NBUVB 治疗时间。需要更长时间的随访。
