• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman.

作者信息

Bogaard Harm J, Legchenko Ekaterina, Ackermann Maximilian, Kühnel Mark P, Jonigk Danny D, Chaudhary Ketul R, Sun Xiaoqing, Stewart Duncan J, Hansmann Georg

机构信息

Amsterdam UMCAmsterdam, the Netherlands.

Hannover Medical SchoolHannover, Germany.

出版信息

Am J Respir Crit Care Med. 2020 Mar 1;201(5):621-624. doi: 10.1164/rccm.201910-1983LE.

DOI:10.1164/rccm.201910-1983LE
PMID:31769697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7047453/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0306/7047453/b6f55fc6350a/rccm.201910-1983LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0306/7047453/b6f55fc6350a/rccm.201910-1983LE_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0306/7047453/b6f55fc6350a/rccm.201910-1983LE_f1.jpg

相似文献

1
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman.成年Sprague-Dawley Sugen-低氧大鼠仍是“首选”：1型肺动脉高压模型：对勒·克拉斯和阿布曼的回复
Am J Respir Crit Care Med. 2020 Mar 1;201(5):621-624. doi: 10.1164/rccm.201910-1983LE.
2
Reply to Bogaard : Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.对博加德的回复：在Sugen/低氧性肺动脉高压大鼠模型中，肺气肿至多只是一种轻微的表型。
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1450-1452. doi: 10.1164/rccm.201907-1367LE.
3
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.在Sugen/低氧大鼠肺动脉高压模型中，肺气肿至多只是一种轻微的表型。
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1447-1450. doi: 10.1164/rccm.201906-1200LE.
4
Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats.间质干细胞细胞外囊泡逆转沙利度胺/缺氧诱导的大鼠肺动脉高压。
Am J Respir Cell Mol Biol. 2020 May;62(5):577-587. doi: 10.1165/rcmb.2019-0154OC.
5
Endothelial cell-related autophagic pathways in Sugen/hypoxia-exposed pulmonary arterial hypertensive rats.舒尼替尼/低氧暴露肺动脉高压大鼠中内皮细胞相关的自噬途径
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L899-L915. doi: 10.1152/ajplung.00527.2016. Epub 2017 Aug 10.
6
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.SU5416/低氧性肺动脉高压大鼠模型中的重度肺气肿
Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE.
7
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats.Rho激酶介导的血管收缩在大鼠重度闭塞性肺动脉高压中起重要作用。
Circ Res. 2007 Mar 30;100(6):923-9. doi: 10.1161/01.RES.0000261658.12024.18. Epub 2007 Mar 1.
8
The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension.肺动脉高压的Sugen 5416/低氧小鼠模型
Methods Mol Biol. 2018;1816:243-252. doi: 10.1007/978-1-4939-8597-5_19.
9
Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema.血管内皮生长因子受体信号传导的早期破坏与成人肺气肿风险
Am J Respir Crit Care Med. 2020 Mar 1;201(5):620-621. doi: 10.1164/rccm.201909-1698LE.
10
RP5063, a novel, multimodal, serotonin receptor modulator, prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats.RP5063 是一种新型多模式 5-羟色胺受体调节剂，可预防 Sugen 5416 低氧诱导的大鼠肺动脉高压。
Eur J Pharmacol. 2017 Sep 5;810:83-91. doi: 10.1016/j.ejphar.2017.05.052. Epub 2017 May 31.

引用本文的文献

1
Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization.实验性肺动脉高压小鼠模型：肺血管造影和右心导管检查。
Pulm Circ. 2021 Sep 8;11(4):20458940211041512. doi: 10.1177/20458940211041512. eCollection 2021 Oct-Dec.
2
Animal models of right heart failure.右心衰竭的动物模型。
Cardiovasc Diagn Ther. 2020 Oct;10(5):1561-1579. doi: 10.21037/cdt-20-400.
3
The selective PGI2 receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats.

本文引用的文献

1
Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.在Sugen/低氧大鼠肺动脉高压模型中，肺气肿至多只是一种轻微的表型。
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1447-1450. doi: 10.1164/rccm.201906-1200LE.
2
Reply to Bogaard : Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.对博加德的回复：在Sugen/低氧性肺动脉高压大鼠模型中，肺气肿至多只是一种轻微的表型。
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1450-1452. doi: 10.1164/rccm.201907-1367LE.
3
Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.
选择性前列环素受体激动剂塞来昔帕能改善 Sugen 5416/缺氧诱导的大鼠肺动脉高压。
PLoS One. 2020 Oct 15;15(10):e0240692. doi: 10.1371/journal.pone.0240692. eCollection 2020.
SU5416/低氧性肺动脉高压大鼠模型中的重度肺气肿
Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE.
4
PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation.过氧化物酶体增殖物激活受体γ激动剂吡格列酮通过脂肪酸氧化逆转肺动脉高压并预防右心衰竭。
Sci Transl Med. 2018 Apr 25;10(438). doi: 10.1126/scitranslmed.aao0303.
5
Role of the Aryl Hydrocarbon Receptor in Sugen 5416-induced Experimental Pulmonary Hypertension.芳基烃受体在 Sugen 5416 诱导的实验性肺动脉高压中的作用。
Am J Respir Cell Mol Biol. 2018 Mar;58(3):320-330. doi: 10.1165/rcmb.2017-0260OC.
6
Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.严重肺动脉高压SU5416大鼠模型中显著的品系特异性差异。
Am J Respir Cell Mol Biol. 2016 Apr;54(4):461-8. doi: 10.1165/rcmb.2014-0488OC.
7
Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus.宫内高血压会降低肺血管内皮生长因子（VEGF）的表达，而抑制VEGF会导致绵羊胎儿患肺动脉高压。
Am J Physiol Lung Cell Mol Physiol. 2003 Mar;284(3):L508-17. doi: 10.1152/ajplung.00135.2002. Epub 2002 Nov 22.
8
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure.用血管内皮生长因子（VEGF）受体抑制剂治疗新生大鼠会导致肺动脉高压和肺结构异常。
Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L555-62. doi: 10.1152/ajplung.00408.2001.
9
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension.抑制血管内皮生长因子受体2并结合慢性缺氧会导致细胞死亡依赖性肺内皮细胞增殖和严重的肺动脉高压。
FASEB J. 2001 Feb;15(2):427-38. doi: 10.1096/fj.00-0343com.
10
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.抑制血管内皮生长因子受体可导致肺细胞凋亡和肺气肿。
J Clin Invest. 2000 Dec;106(11):1311-9. doi: 10.1172/JCI10259.